Wróblewski Z, Mejbaum-Katzenellenbogen W, Halikowski B
Arch Immunol Ther Exp (Warsz). 1986;34(1):85-91.
The studies on IgG-3 subclass in the course of acute lymphoblastic leukemia (ALL) in children were performed. The presence of this IgG subclass was not shown, using chromatography on AGP-Sepharose for its isolation and Protein A-Sepharose for its identification. The possibilities of excretion of this IgG subclass with urine and proteolytic digestion in neutral pH by serum enzymes were excluded. Acid alpha-1-glycoprotein (AGP) isolated from serum of children with ALL interacts with IgG-3 of normal serum.
开展了关于儿童急性淋巴细胞白血病（ALL）病程中IgG-3亚类的研究。使用AGP-琼脂糖凝胶柱层析法分离该IgG亚类并采用蛋白A-琼脂糖凝胶柱层析法进行鉴定，结果未显示出该IgG亚类的存在。排除了该IgG亚类经尿液排泄以及在中性pH条件下被血清酶进行蛋白水解消化的可能性。从ALL患儿血清中分离出的酸性α-1-糖蛋白（AGP）与正常血清的IgG-3相互作用。
