Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Addison House 2.14, SE1 1UL, UK..
Stress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
J Affect Disord. 2022 Jan 15;297:112-117. doi: 10.1016/j.jad.2021.10.003. Epub 2021 Oct 12.
Previous studies have shown associations between major depression and C-reactive protein (CRP) levels. Few studies have considered the extent to which shared genetic and environmental factors contribute to this association, nor have they considered the relationship outside of European populations. We examined the association between CRP levels and depression and their aetiology in a Sri Lankan population.
Data were collected from 2577 twins and 899 singletons in Colombo, Sri Lanka. Depression symptoms were assessed using the revised Beck Depression Inventory (BDI-II). High-sensitive CRP blood levels were assessed using immunoturbidimetry. Linear regressions were performed to test the association between CRP and depression. The heritability of CRP levels was estimated using Structural Equation Modelling.
CRP was significantly associated with BMI (p < 0.01) but not depression (p > 0.05). In males, variance in CRP levels was explained by shared environment (51% 95%CIs: 13-62) and non-shared environment (45% 95%CIs: 36-54). In contrast, in females, CRP variance was explained by genetic (41% 95%CIs: 10-52) and non-shared environment (56% 95%CIs: 47-67). A genetic correlation between CRP and BMI was observed in females only.
CRP level was based on a single data collection point, longer term data collection would give a more accurate picture of an individual's state of inflammation.
The lack of association between depression and CRP strengthens the hypothesis that inflammation might contribute to the development of some, but not all types of depression. CRP levels were moderated by the environment, suggesting interventions aimed at reducing CRP levels and risk for inflammatory conditions, particularly in males.
先前的研究表明，重度抑郁症与 C 反应蛋白（CRP）水平之间存在关联。很少有研究考虑到共同的遗传和环境因素在多大程度上促成了这种关联，也没有考虑到欧洲人群以外的这种关联。我们在斯里兰卡人群中研究了 CRP 水平与抑郁之间的关联及其病因。
数据来自于科伦坡的 2577 对双胞胎和 899 名单胞胎。使用修订后的贝克抑郁量表（BDI-II）评估抑郁症状。使用免疫比浊法测定高敏 CRP 血水平。进行线性回归以检验 CRP 与抑郁之间的关联。使用结构方程模型估计 CRP 水平的遗传力。
CRP 与 BMI 显著相关（p<0.01），但与抑郁无关（p>0.05）。在男性中，CRP 水平的变异由共享环境（51% 95%置信区间：13-62）和非共享环境（45% 95%置信区间：36-54）解释。相比之下，在女性中，CRP 变异由遗传（41% 95%置信区间：10-52）和非共享环境（56% 95%置信区间：47-67）解释。仅在女性中观察到 CRP 与 BMI 之间的遗传相关性。
CRP 水平基于单次数据采集点，更长时间的数据采集将更准确地反映个体的炎症状态。
抑郁与 CRP 之间缺乏关联，这进一步支持了炎症可能有助于某些而非所有类型的抑郁发生的假说。CRP 水平受环境调节，这表明干预措施旨在降低 CRP 水平和炎症性疾病的风险，特别是在男性中。
