新型冠状病毒肺炎幸存者状态和性别对印度尼西亚临床医学生接种科兴疫苗后 1、2、3 个月中和抗体滴度的影响。
The role of COVID-19 survivor status and gender towards neutralizing antibody titers 1, 2, 3 months after Sinovac vaccine administration on clinical-year medical students in Indonesia.
机构信息
Faculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman street, Karawaci, Tangerang, Indonesia.
Department of Internal Medicine, Faculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman street, Karawaci, Tangerang, Indonesia.
出版信息
Int J Infect Dis. 2021 Dec;113:336-338. doi: 10.1016/j.ijid.2021.10.009. Epub 2021 Oct 12.
BACKGROUND
Sinovac was the first vaccine used in Indonesia against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data regarding the effects of certain variables such as clinical demographics on antibody levels in individuals vaccinated with Sinovac are scarce. This study aimed to investigate the impact of gender and previous SARS-CoV-2 infection status on neutralizing antibody titers 1, 2, and 3 months after administration of the Sinovac vaccine.
METHOD
A cross-sectional study was conducted from February to May 2021. Data on neutralizing antibody levels, previous SARS-CoV-2 infection status, and gender were retrieved from the monthly quantitative serology evaluation database of Siloam Hospitals Lippo Village, Tangerang, Indonesia. The role of each variable was analyzed using the t-test or Mann-Whitney U test, depending on data distribution.
RESULT
Data from 350 participants were collected for the study. Participants with a history of a positive SARS-CoV-2 RT-PCR test had significantly higher neutralizing antibody titers in the first (144 U/mL, p = 0.036) and second months (144 U/mL, p = 0.005) after vaccination compared with those without a history of positive RT-PCR test. Female participants also had significantly higher neutralizing antibody titers in the first, second, and third months (43 U/mL, 42 U/mL, and 39 U/mL, respectively; p = 0.001, p = 0.002, and p = 0.003, respectively) after vaccination compared to males.
CONCLUSION
COVID-19 survivor status and the female gender were associated with higher neutralizing antibody titers after Sinovac vaccine administration.
背景
科兴是印度尼西亚首次用于对抗严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的疫苗。然而，关于某些变量（如临床人口统计学）对科兴疫苗接种者抗体水平的影响的数据却很少。本研究旨在调查性别和先前 SARS-CoV-2 感染状况对科兴疫苗接种后 1、2 和 3 个月时中和抗体滴度的影响。
方法
这是一项横断面研究，于 2021 年 2 月至 5 月进行。从印度尼西亚唐格朗的 Siloam 医院利波村每月定量血清学评估数据库中检索中和抗体水平、先前 SARS-CoV-2 感染状况和性别数据。根据数据分布，使用 t 检验或曼-惠特尼 U 检验分析每个变量的作用。
结果
本研究共收集了 350 名参与者的数据。有 SARS-CoV-2 RT-PCR 检测阳性史的参与者在接种后第 1 个月（144 U/mL，p=0.036）和第 2 个月（144 U/mL，p=0.005）的中和抗体滴度显著高于无阳性 RT-PCR 检测史的参与者。女性参与者在接种后第 1、2 和 3 个月的中和抗体滴度也显著高于男性（分别为 43 U/mL、42 U/mL 和 39 U/mL；p=0.001、p=0.002 和 p=0.003）。
结论
COVID-19 幸存者状态和女性性别与科兴疫苗接种后较高的中和抗体滴度相关。
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