配合物与 DNA 的共价和非共价相互作用：概述。
Covalent and noncovalent interactions of coordination compounds with DNA: An overview.
机构信息
Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, Slovakia; Department of Inorganic Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.
Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, Slovakia.
出版信息
J Inorg Biochem. 2021 Dec;225:111624. doi: 10.1016/j.jinorgbio.2021.111624. Epub 2021 Oct 4.
Deoxyribonucleic acid plays a central role in crucial cellular processes, and many drugs exert their effects through binding to DNA. Since the discovery of cisplatin and its derivatives considerable attention of researchers has been focused on the development of novel anticancer metal-based drugs. Transition metal complexes, due to their great diversity in size and structure, have a big potential to modify DNA through diverse types of interactions, making them the prominent class of compounds for DNA targeted therapy. In this review we describe various binding modes of metal complexes to duplex DNA based on covalent and noncovalent interactions or combination of both. Specific examples of each binding mode as well as possible cytotoxic effects of metal complexes in tumor cells are presented.
脱氧核糖核酸在关键的细胞过程中起着核心作用，许多药物通过与 DNA 结合来发挥作用。自顺铂及其衍生物被发现以来，研究人员一直致力于开发新型抗癌金属基药物。由于过渡金属配合物在大小和结构上具有很大的多样性，它们具有通过多种类型的相互作用来修饰 DNA 的巨大潜力，使它们成为用于 DNA 靶向治疗的突出化合物类别。在这篇综述中，我们根据共价和非共价相互作用或两者的组合描述了金属配合物与双链 DNA 的各种结合模式。介绍了每种结合模式的具体实例以及金属配合物在肿瘤细胞中的可能细胞毒性作用。
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