Demetrius Lloyd A, Eckert Anne, Grimm Amandine
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
University of Basel, Transfaculty Research Platform Molecular and Cognitive Neuroscience, 4002 Basel, Switzerland; Neurobiology Lab for Brain Aging and Mental Health, Psychiatric University Clinics, 4002 Basel, Switzerland.
Trends Endocrinol Metab. 2021 Dec;32(12):963-979. doi: 10.1016/j.tem.2021.09.004. Epub 2021 Oct 12.
Studies on the sporadic form of Alzheimer's disease (AD) have revealed three classes of risk factor: age, genetics, and sex. These risk factors point to a metabolic dysregulation as the origin of AD. Adaptive alterations in cerebral metabolism are the rationale for the Metabolic Reprogramming (MR) Theory of the origin of AD. The theory contends that the progression toward AD involves three adaptive events: a hypermetabolic phase, a prolonged prodromal phase, and a metabolic collapse. This article exploits the MR Theory to elucidate the effect of hormonal changes on the origin and progression of AD in women. The theory invokes bioenergetic signatures of the menopausal transition to propose sex-specific diagnostic program and therapeutic strategies.
对散发性阿尔茨海默病（AD）的研究揭示了三类风险因素：年龄、遗传和性别。这些风险因素表明代谢失调是AD的起源。大脑代谢的适应性改变是AD起源的代谢重编程（MR）理论的依据。该理论认为，AD的发展涉及三个适应性事件：高代谢阶段、长期前驱期和代谢崩溃。本文利用MR理论阐明激素变化对女性AD起源和发展的影响。该理论援引绝经过渡的生物能量特征，提出针对性别的诊断方案和治疗策略。
