Terstege Dylan J, Galea Liisa A M, Epp Jonathan R
Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Alzheimers Dement. 2024 Dec;20(12):8979-8986. doi: 10.1002/alz.14258. Epub 2024 Oct 29.
Not all individuals who experience mild cognitive impairment (MCI) transition through progressive stages of cognitive decline at the same rate, if at all. Previous observational studies have identified the retrosplenial cortex (RSC) as an early site of hypometabolism in MCI which seems to be predictive of later transition to Alzheimer's disease (AD).
We examined N = 399 MCI subjects with baseline F-fluorodeoxyglucose positron emission tomography. Subjects were classified based on whether their diagnosis converted from MCI to AD.
Whole-brain metabolism was decreased in converters (MCI-AD). This effect was more prominent at the RSC, where MCI-AD subjects showed even greater hypometabolism. Observations of RSC hypometabolism and its utility in predicting transition from MCI-AD withstood statistical analyses in a large retrospective study.
These results point to the utility of incorporating RSC hypometabolism into predictive models of AD progression risk and call for further examination of mechanisms underlying this relationship.
Not all individuals who develop MCI will progress to AD. Individuals with MCI who progress to AD show early whole-brain hypometabolism. Early hypometabolism is particularly prominent at the RSC.
并非所有经历轻度认知障碍（MCI）的个体都会以相同的速度（如果有的话）经历认知衰退的进展阶段。先前的观察性研究已将扣带回后皮质（RSC）确定为MCI中代谢减退的早期部位，这似乎可预测后期向阿尔茨海默病（AD）的转变。
我们检查了399名患有基线氟脱氧葡萄糖正电子发射断层扫描的MCI受试者。根据他们的诊断是否从MCI转变为AD对受试者进行分类。
在转变者（MCI-AD）中全脑代谢降低。这种效应在RSC更为明显，MCI-AD受试者在RSC表现出更严重的代谢减退。在一项大型回顾性研究中，RSC代谢减退及其在预测从MCI转变为AD中的作用的观察结果经受住了统计分析。
这些结果表明将RSC代谢减退纳入AD进展风险预测模型的实用性，并呼吁进一步研究这种关系背后的机制。
并非所有发生MCI的个体都会进展为AD。进展为AD的MCI个体表现出早期全脑代谢减退。早期代谢减退在RSC尤为明显。
