GPR56/ADGRG1 在健康和疾病中的作用。
The role of GPR56/ADGRG1 in health and disease.
机构信息
Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India.
Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
出版信息
Biomed J. 2021 Oct;44(5):534-547. doi: 10.1016/j.bj.2021.04.012. Epub 2021 May 4.
GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.
GPR56/ADGRG1 是一种多功能的黏附 G 蛋白偶联受体，在中枢和外周神经系统、生殖系统、肌肉肥大、免疫调节和造血干细胞生成的生理功能中具有重要作用。相比之下，GPR56 的异常表达或功能失调与多种病理过程有关，包括双侧额顶多小脑回、抑郁和肿瘤发生。在这篇综述文章中，我们总结和讨论了 GPR56 在健康和疾病中的作用的现有认识。
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