Erbaş İrem Ceren, Tüfekçi Özlem, Akyol Şefika, Asrak Hatice Karaoğlu, Güzin Ayşe Çakil, Alataş Şilem Özdem, Yilmaz Şebnem, Ören Hale, Belet Nurşen
Divisions of Pediatric Infectious Disease.
Pediatric Hematology and Oncology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
J Pediatr Hematol Oncol. 2022 Oct 1;44(7):e976-e981. doi: 10.1097/MPH.0000000000002348. Epub 2021 Oct 15.
With the rapid spread of coronavirus disease 2019 (COVID-19) around the globe, concerns about the management of patients with malignancy have risen significantly. This study aimed to investigate the possible impact of the COVID-19 pandemic and prevention policies on the incidence and etiology of febrile neutropenia (FN) episodes in children with acute leukemia. Children who had acute leukemia and were diagnosed as FN in a tertiary center from March 2018 to March 2021 were included in the study. FN episodes were grouped as prepandemic and postpandemic based on the date that pandemic was declared. Relevant data were collected retrospectively. We evaluated 113 FN episodes (75.2% were prepandemic) of 46 patients, a median of 4.7 (2.6 to 12.6) years of age. The number of FN episodes per patient did not differ between prepandemic and postpandemic periods ( P =0.476). There was no significant difference among the 2 groups regarding the microbiologic causes, focus of fever, and clinical outcomes in FN episodes. Two of the patients were diagnosed as COVID-19 and recovered without any complications. In conclusion, we showed that the incidence and etiology of FN episodes were similar before and during the COVID-19 pandemic in children with acute leukemia.
随着2019冠状病毒病（COVID-19）在全球迅速蔓延，对恶性肿瘤患者管理的担忧显著增加。本研究旨在调查COVID-19大流行及预防政策对急性白血病儿童发热性中性粒细胞减少症（FN）发作的发生率和病因的可能影响。本研究纳入了2018年3月至2021年3月在一家三级中心被诊断为急性白血病且确诊为FN的儿童。根据宣布大流行的日期，将FN发作分为大流行前和大流行后两组。相关数据进行回顾性收集。我们评估了46例患者的113次FN发作（75.2%为大流行前发作），患者年龄中位数为4.7（2.6至12.6）岁。大流行前和大流行后时期每位患者的FN发作次数无差异（P = 0.476）。两组在FN发作的微生物学病因、发热部位和临床结局方面无显著差异。其中两名患者被诊断为COVID-19，且康复后无任何并发症。总之，我们表明，COVID-19大流行之前和期间，急性白血病儿童FN发作的发生率和病因相似。
