Kibby Danielle, Trinkman Heidi, Ray Anish, Hamby Tyler, Orr Kaci
Cook Children's Medical Center, Fort Worth.
Texas A and M Health Science Center School of Medicine, Bryan, TX.
J Pediatr Hematol Oncol. 2023 May 1;45(4):e479-e482. doi: 10.1097/MPH.0000000000002627. Epub 2023 Jan 20.
Historically, febrile neutropenia (FN) has constituted a common but life-threatening emergency in pediatric oncology patients. As such, hygiene precautions have consistently been recommended for immunosuppressed patients. These precautions, however, were more strictly and widely adopted during the coronavirus disease 2019 pandemic. Universal mask mandates, emphasis on hand hygiene, and encouragement of social distancing were some of the many initiatives introduced in an effort to reduce transmission of the virus. There is little data available regarding whether the universal adoption of these precautions was associated with any changes in the incidence of hospitalizations for FN in pediatric oncology patients. A retrospective chart review was utilized to evaluate newly diagnosed patients admitted for FN in the first 14 months of the pandemic compared with the same time period during the previous year. During the pandemic, the admission rate for FN was 28.9%, compared with 29.1% prepandemic ( P = 0.97). There was no significant difference in causative organisms when comparing time periods. In addition, the presence of a state government-enforced mask mandate was associated with an increased admission rate for FN during the pandemic period.
从历史上看，发热性中性粒细胞减少症（FN）在儿科肿瘤患者中一直是一种常见但危及生命的紧急情况。因此，一直建议对免疫抑制患者采取卫生预防措施。然而，在2019年冠状病毒病大流行期间，这些预防措施得到了更严格和广泛的采用。普遍佩戴口罩的规定、对手部卫生的强调以及对社交距离的鼓励是为减少病毒传播而采取的众多举措中的一部分。关于这些预防措施的普遍采用是否与儿科肿瘤患者FN住院率的任何变化相关的数据很少。一项回顾性病历审查被用于评估在大流行的前14个月因FN入院的新诊断患者，并与上一年的同一时期进行比较。在大流行期间，FN的入院率为28.9%，而大流行前为29.1%（P = 0.97）。比较不同时间段时，致病微生物没有显著差异。此外，州政府强制实施口罩规定与大流行期间FN的入院率增加有关。
