Mastropaolo W, Fernandez Z, Miller E L
Clin Chem. 1986 Nov;32(11):2110-1.
CA-125 is a glycoprotein associated with various ovarian tumors. A commercial radioimmunoassay involving a monoclonal antibody is available for it. In our laboratory, a normal-value study was conducted as part of a routine evaluation of this assay. One healthy subject had a serum CA-125 concentration greater than 300 kU/L, more than eightfold the upper limit of normal (35 kU/L). This increase, which coincided with the onset of the menstrual period, subsided to within the normal range by the end of the menstrual cycle. The half-life of CA-125, calculated from this decrease, was 6.4 days. Similar observations were made in the same subject over several menstrual cycles. Results of clinical and ultrasound examinations of the subject for ovarian tumors were negative. No clinical evidence of malignancy was present eight months after the initial discovery of an increased CA-125. None of the other 39 healthy subjects had a CA-125 value greater than 51 kU/L. Five of these subjects had CA-125 determined several times during their menstrual cycles; none exhibited pronounced variations in CA-125 concentrations. Evidently CA-125 can be extremely increased in a healthy woman, and possible effects of the menstrual period on serum CA-125 concentrations should be considered in pre-menopausal patients.
CA - 125是一种与多种卵巢肿瘤相关的糖蛋白。有一种涉及单克隆抗体的商业放射免疫测定法可用于检测它。在我们实验室，作为该检测方法常规评估的一部分，进行了一项正常值研究。一名健康受试者的血清CA - 125浓度大于300 kU/L，超过正常上限（35 kU/L）的八倍多。这种升高与月经周期开始同时出现，在月经周期结束时降至正常范围内。根据这种下降情况计算出的CA - 125半衰期为6.4天。在同一个受试者的几个月经周期中都有类似的观察结果。对该受试者进行的卵巢肿瘤临床和超声检查结果均为阴性。在最初发现CA - 125升高八个月后，没有恶性肿瘤的临床证据。其他39名健康受试者中没有一人的CA - 125值大于51 kU/L。其中五名受试者在月经周期中多次检测CA - 125；没有人的CA - 125浓度表现出明显变化。显然，健康女性体内的CA - 125可能会极度升高，对于绝经前患者，应考虑月经周期对血清CA - 125浓度的可能影响。
