Hauzman Erik E, Lagarde Ana R, Nagy Katalin, Fancsovits Péter, Murber Akos, Jánoki Gyözö, Papp Zoltán, Urbancsek János
First Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary.
J Assist Reprod Genet. 2005 Jun;22(6):265-8. doi: 10.1007/s10815-005-5151-8.
To assess whether serum levels of CA-125, a proposed marker of endometrial receptivity, are associated with pregnancy after IVF.
42 IVF pregnancies were matched with nonpregnant controls. Twenty-eight additional unmatched pregnancies were included for the comparison of pregnancy outcomes. CA-125 concentrations were measured on stimulation day 1 (SD1) and at oocyte pickup (OPU). We analyzed association between CA-125 levels and establishment of pregnancy and its outcome; correlation between CA-125 concentrations and other parameters; differences in CA-125 levels between SD1 and OPU.
In pregnant, but not in nonpregnant patients, CA-125 levels decreased significantly from SD1 to OPU. There was no significant difference in CA-125 levels at either time point between pregnant and nonpregnant subjects. No significant correlation was found between CA-125 levels and any other clinical or laboratory parameters.
CA-125 measurements at the beginning of stimulation or at oocyte retrieval are not useful in predicting IVF outcome.
评估血清CA - 125水平（一种子宫内膜容受性的潜在标志物）是否与体外受精（IVF）后的妊娠相关。
42例IVF妊娠患者与未妊娠对照组进行匹配。另外纳入28例未匹配的妊娠患者以比较妊娠结局。在刺激第1天（SD1）和取卵时（OPU）测量CA - 125浓度。我们分析了CA - 125水平与妊娠建立及其结局之间的关联；CA - 125浓度与其他参数之间的相关性；SD1和OPU之间CA - 125水平的差异。
在妊娠患者中，而非未妊娠患者中，CA - 125水平从SD1到OPU显著降低。妊娠和未妊娠受试者在两个时间点的CA - 125水平均无显著差异。未发现CA - 125水平与任何其他临床或实验室参数之间存在显著相关性。
在刺激开始时或取卵时测量CA - 125对预测IVF结局无用。
