Kalla N R, Rovan E, Ranga A, Bhatia S, Frick J
Contraception. 1986 Aug;34(2):177-90. doi: 10.1016/0010-7824(86)90070-3.
This study was undertaken to determine the effects of gossypol alone and gossypol in combination with prostaglandin and aspirin. Rats were administered gossypol (40 mg/kg/day), gossypol and prostaglandin (PGF2 alpha-2 mg/kg/day), gossypol and aspirin (300 mg/kg) for 4 weeks. A marked effect of the gossypol-prostaglandin combination was observed on sperm motility and spermatogenesis. The effect of the gossypol-aspirin combination was less pronounced. The ratio of body weight to testicular and epididymal weights between the different groups showed no marked difference. No effect of drug treatment on plasma testosterone, LH and FSH was observed. The data presented in this paper suggest that prostaglandin plays an important role in the antifertility effects of gossypol.
本研究旨在确定单独使用棉酚以及棉酚与前列腺素和阿司匹林联合使用的效果。给大鼠分别施用棉酚（40毫克/千克/天）、棉酚与前列腺素（前列腺素F2α - 2毫克/千克/天）、棉酚与阿司匹林（300毫克/千克），持续4周。观察到棉酚 - 前列腺素组合对精子活力和精子发生有显著影响。棉酚 - 阿司匹林组合的效果则不太明显。不同组之间体重与睾丸及附睾重量的比值没有显著差异。未观察到药物治疗对血浆睾酮、促黄体生成素和促卵泡生成素有影响。本文所呈现的数据表明，前列腺素在棉酚的抗生育作用中起重要作用。
