Long R E, Knutsen G, Robinson M
Environ Health Perspect. 1986 Sep;68:117-23. doi: 10.1289/ehp.8668117.
The term myeloid hyperplasia has been used interchangeably with many other terms to describe an increased production of granulocytes, megakaryocytes, and erythrocytes in the spleen and other organs in the mouse. This process is occasionally misdiagnosed as granulocytic leukemia. This paper reviews some of the terms used interchangeably with myeloid hyperplasia and describes criteria that can be used to differentiate myeloid hyperplasia from granulocytic leukemia. Additionally, the results of a study in which myeloid hyperplasia was induced following the formation of skin tumors in SENCAR mice is discussed. In this study, positive correlations were found between skin lesions, the spleen weight, and histologic appearance of the spleen. The liver rarely showed microscopic changes of myeloid hyperplasia unless the spleen weighed at least 1.0% of the body weight.
术语“髓样增生”已与许多其他术语互换使用，以描述小鼠脾脏和其他器官中粒细胞、巨核细胞和红细胞生成增加的情况。这个过程偶尔会被误诊为粒细胞白血病。本文回顾了一些与髓样增生互换使用的术语，并描述了可用于区分髓样增生与粒细胞白血病的标准。此外，还讨论了一项在SENCAR小鼠皮肤肿瘤形成后诱导髓样增生的研究结果。在这项研究中，发现皮肤病变、脾脏重量和脾脏组织学外观之间存在正相关。除非脾脏重量至少占体重的1.0%，否则肝脏很少出现髓样增生的微观变化。
