Svoboda V, Bubeníková D, Kotasková Z
Neoplasma. 1982;29(2):175-82.
Cytologic and histologic evaluation of granulocytic leukemia was carried out in 22 plutonium-treated mice and in 17 controls. The contaminated animals were injected i. v. with 5.4 kBq 239Pu/mouse (180 kBq/kg) at the age of 70 days. Morphologic evidence of the disease was based on the identification of immature abnormal granulocytes in the bone marrow and spleen and on the histologically ascertained leukemic infiltration at least in one of the tissues examined (liver, lung, kidney, lymph nodes). Whatever further symptoms are thought to be of non-specific value. The leukemic process could be mostly evaluated as more florid in the spleen than in the bone marrow. The less active leukemic proliferation in 239Pu-treated mice than in diseased controls is the most important finding of this study. The results are discussed.
对22只接受钚处理的小鼠和17只对照小鼠进行了粒细胞白血病的细胞学和组织学评估。受污染的动物在70日龄时静脉注射5.4 kBq 239Pu/只小鼠（180 kBq/kg）。该疾病的形态学证据基于在骨髓和脾脏中鉴定出未成熟的异常粒细胞，以及至少在一个检查组织（肝脏、肺、肾脏、淋巴结）中通过组织学确定的白血病浸润。无论其他症状被认为具有何种非特异性价值。白血病进程在脾脏中大多比在骨髓中更为显著。本研究最重要的发现是，接受239Pu处理的小鼠白血病增殖活性低于患病对照小鼠。对结果进行了讨论。
