Kollegger H, Preis P, Maida E, Zielinski C C, Linkesch W, Bettelheim P, Aiginger P
Eur Neurol. 1986;25(5):320-6. doi: 10.1159/000116029.
The course of leukemic disease in a male adolescent with meningeal leukemia is described. The bone marrow aspirates showed a conversion from an acute lymphatic leukemia to an eosinophilic leukemia. Four weeks after the peripheral shift of phenotype two different cell clones were detected in one CSF smear. While under ultrahigh dose araC therapy the patient died 3 months after conversion. Possible explanation for the shift of phenotype and the peculiar leptomeningeal infiltration are discussed.
描述了一名患有脑膜白血病的男性青少年白血病的病程。骨髓穿刺显示从急性淋巴细胞白血病转变为嗜酸性粒细胞白血病。表型在外周转变四周后，在一份脑脊液涂片上检测到两种不同的细胞克隆。在超高剂量阿糖胞苷治疗期间，患者在转变后3个月死亡。讨论了表型转变和特殊软脑膜浸润的可能解释。
