Ricevuti G, Savoldi F, Piccolo G, Marchioni E, Rizzo S C
Arch Neurol. 1986 May;43(5):466-70. doi: 10.1001/archneur.1986.00520050046020.
Owing to improved therapy and lengthened life span, the incidence of neuromeningeal involvement in leukemia is increasing. Careful examination of the cerebrospinal fluid (CSF) is important for an early diagnosis. Among the available techniques, the use of cytocentrifugation enables us to demonstrate central nervous system leukemia even if the white blood cell count in the CSF is under 10/cu mm. We describe the results obtained by examining 631 CSF samples from 87 patients affected by acute leukemia; central nervous system luekemia was found in 22.7% of the patients suffering from acute lymphocytic leukemia and in 6.4% of those with acute nonlymphocytic leukemia (ANLL), but this ratio is higher in ANLL compared with the survival as measured in months (a ratio of 2.0 in ANLL compared with 0.50 in acute lymphocytic leukemia). A "leukemic" CSF was found in 51.5% of prophylactically treated patients and in 73.1% of the untreated ones.
由于治疗方法的改进和寿命的延长，白血病患者神经脑膜受累的发生率正在上升。仔细检查脑脊液（CSF）对于早期诊断很重要。在现有的技术中，使用细胞离心法即使脑脊液中的白细胞计数低于10/立方毫米，也能使我们诊断出中枢神经系统白血病。我们描述了对87例急性白血病患者的631份脑脊液样本进行检查所获得的结果；在急性淋巴细胞白血病患者中，22.7%被发现患有中枢神经系统白血病，在急性非淋巴细胞白血病（ANLL）患者中这一比例为6.4%，但与以月为单位衡量的生存期相比，ANLL中的这一比例更高（ANLL为2.0，而急性淋巴细胞白血病为0.50）。在接受预防性治疗的患者中，51.5%的脑脊液样本被发现为“白血病性”，在未接受治疗的患者中这一比例为73.1%。
