Division of Pediatric Gastroenterology and Nutrition, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Bon Secours Pediatric Gastroenterology Associates, Richmond, Virginia, USA.
J Gastroenterol Hepatol. 2022 Mar;37(3):420-427. doi: 10.1111/jgh.15706. Epub 2021 Nov 6.
Eosinophilic esophagitis (EoE) is a disease entity that has become increasingly recognized in the pediatric population over the last decade and was first recognized as early as 1990. EoE is a clinicopathologic diagnosis with signs and symptoms varying between age groups. The clinical presentation of EoE is variable ranging from milder nonspecific symptoms, such as abdominal pain, vomiting, and dyspepsia, to more severe presentations such as failure to thrive, dysphagia and even food impaction and is dependent on age of diagnosis 2. There is growing body of evidence with regards to the pathophysiology, diagnostic modalities, and treatment options for EoE in the past decade. In this review article, we aim to discuss the disease burden, pathophysiology, diagnostic strategies, and currently available treatment options for EoE based on existing literature.
嗜酸细胞性食管炎 (EoE) 是一种疾病实体，在过去十年中，在儿科人群中越来越受到认识，早在 1990 年就被首次认识。EoE 是一种临床病理诊断，其体征和症状在不同年龄组之间有所不同。EoE 的临床表现多种多样，从较轻的非特异性症状，如腹痛、呕吐和消化不良，到更严重的表现，如生长不良、吞咽困难，甚至食物嵌塞，这取决于诊断时的年龄 2。在过去十年中，对于 EoE 的病理生理学、诊断方法和治疗选择，有越来越多的证据。在这篇综述文章中，我们旨在根据现有文献讨论 EoE 的疾病负担、病理生理学、诊断策略和现有的治疗选择。
