State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
Fitoterapia. 2021 Nov;155:105063. doi: 10.1016/j.fitote.2021.105063. Epub 2021 Oct 14.
Five new spirocyclic polycyclic polyprenylated acylphloroglucinols, Hyperpatulones C-G (1-5), were obtained from the leaves of Hypericum patulum. Their structures were characterized by the comprehensive analysis of their IR, NMR, CD spectra and HRESIMS data. All the new compounds were evaluated for the α-glycosidase inhibitory activities. Among them, compounds 3-5 showed α-glucosidase inhibitory activities, with IC values of 14.06-37.69 μM.
从贯叶连翘（Hypericum patulum）的叶子中分离得到五个新的螺环多环多聚异戊烯基酰基间苯三酚，分别命名为 Hyperpatulones C-G（1-5）。通过对它们的 IR、NMR、CD 谱和 HRESIMS 数据的综合分析，确定了它们的结构。所有新化合物均进行了α-糖苷酶抑制活性评价。其中，化合物 3-5 对α-葡萄糖苷酶表现出抑制活性，IC 值为 14.06-37.69 μM。
