Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, 06500 Ankara, Turkey.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, 06500 Ankara, Turkey.
J Stomatol Oral Maxillofac Surg. 2022 Sep;123(4):473-477. doi: 10.1016/j.jormas.2021.10.005. Epub 2021 Oct 14.
One of the most common problems in patients with inherited coagulation disorders, especially hemophilia, is joint problems. This study aims to investigate whether temporomandibular joint (TMJ) is affected in patients with hemophilia or other coagulation factor disorders.
MATERIAL & METHODS: In this study, a patient group and a control group were formed. The patient group consisted of 44 individuals with hemophilia or other coagulation disorders (von Willebrand disease and rare factor deficiencies) and the control group consisted of 45 healthy individuals. In both groups, TMJ health was evaluated through a questionnaire and clinical examination.
The prevalence of signs and symptoms of temporomandibular disorders (TMD) that we evaluated was higher in the patient group than in the healthy individuals. Pain in the jaw, temple, in the ear or in front of the ear; pain in the jaw, temple, ear or front of the ear by opening the mouth or moving the jaw forward/sideways; closed locking (subjective); jaw joint noises (subjective) and TMJ noises during open & close movements on the right side in clinical examination were statistically significantly higher in the patient group than in the control group.
There are very limited studies on temporomandibular joint health in patients with coagulation factor deficiency. In this study, it was observed that patients with inherited coagulation disorders, especially hemophilia, were more likely to develop TMD than healthy individuals. This situation was thought to be due to the increased susceptibility to TMJ bleeding in patients with coagulation factor deficiency.
遗传性凝血障碍患者（尤其是血友病患者）最常见的问题之一是关节问题。本研究旨在探讨血友病或其他凝血因子障碍患者是否存在颞下颌关节（TMJ）问题。
本研究将患者分为两组，一组为 44 名血友病或其他凝血因子障碍（血管性血友病和罕见因子缺乏症）患者，另一组为 45 名健康者。在两组中，均通过问卷调查和临床检查评估 TMJ 健康状况。
我们评估的颞下颌关节紊乱症（TMD）体征和症状在患者组中的发生率高于健康对照组。颌、太阳穴、耳朵或耳朵前疼痛；张口或前伸/侧移颌时疼痛；关节闭锁（主观）；关节弹响（主观）以及右侧开闭口运动时 TMJ 噪声在临床检查中，患者组的发生率均明显高于对照组。
关于凝血因子缺乏患者的 TMJ 健康问题，研究非常有限。本研究观察到，遗传性凝血障碍患者，尤其是血友病患者，发生 TMD 的可能性高于健康者。这种情况被认为是由于凝血因子缺乏症患者 TMJ 出血的易感性增加所致。
