College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Beijing Forestry University, Beijing 100083, China.
College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Beijing Forestry University, Beijing 100083, China.
Food Chem. 2022 Mar 15;372:131343. doi: 10.1016/j.foodchem.2021.131343. Epub 2021 Oct 6.
Stilbene-glycoside (THSG) is a promising dietary supplement with remarkable biological properties, however, its poor stability and low oral bioavailability hinder its application as an ingredient in functional foods. Herein, stilbene-glycoside-loaded nanoparticles (THSG-NPs) coated with carboxymethyl chitosan (CMC) and chitosan hydrochloride (CHC) using a complex coacervation method were successfully prepared for enhancing the stability of THSG. The optimized preparation parameters were 2.5 mg/mL CMC, 1.0 mg/mL CHC, 1.5 mg/mL THSG and preparation temperature of 25 °C, under which the experimentally designed particles averaged 381.9 nm with encapsulation efficiency (EE) of 68.6%. Solid-state characterization was assessed by Fourier transform infrared spectroscope and Differential scanning calorimetry. THSG-NPs showed significant protective effects against heat and solar radiation and exhibited remarkable pH-dependent and controlled release. This work demonstrated that enhanced stability and delayed release of THSG could be achieved using THSG-NPs, which could contribute to its potential application in the functional foods industry.
二苯乙烯苷（THSG）是一种具有显著生物学特性的有前途的膳食补充剂，然而，其较差的稳定性和低口服生物利用度阻碍了其作为功能性食品成分的应用。本文采用复凝聚法，以羧甲基壳聚糖（CMC）和盐酸壳聚糖（CHC）为载体，成功制备了负载二苯乙烯苷的纳米粒（THSG-NPs），以提高 THSG 的稳定性。优化的制备参数为 CMC 2.5mg/mL、CHC 1.0mg/mL、THSG 1.5mg/mL 和 25°C 的制备温度，在此条件下，实验设计的粒子平均粒径为 381.9nm，包封率（EE）为 68.6%。采用傅里叶变换红外光谱仪和差示扫描量热法对其进行了固态表征。THSG-NPs 对热和太阳辐射具有显著的保护作用，表现出显著的 pH 值依赖性和控制释放。这项工作表明，THSG-NPs 可以实现 THSG 的稳定性增强和延迟释放，这可能有助于其在功能性食品工业中的潜在应用。
