Huang Yan, Liu Feng, Chen A-Mei, Yang Peng-Fei, Peng Yang, Gong Jian-Ping, Li Zhi, Zhong Guo-Chao
Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Emergency, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Clin Nutr. 2021 Nov;40(11):5595-5604. doi: 10.1016/j.clnu.2021.09.037. Epub 2021 Sep 24.
BACKGROUND & AIMS: Type 2 diabetes prevention diet confers a lower risk of type 2 diabetes, which exhibits overlapping mechanisms with pancreatic cancer. We performed a prospective study to examine whether adherence to this dietary pattern is associated with a reduced risk of pancreatic cancer.
A population-based cohort of 101,729 American adults was identified. A dietary diabetes risk reduction score was computed to reflect adherence to this dietary pattern, with higher scores representing greater adherence. Cox regression was used to compute hazard ratios (HRs) for pancreatic cancer incidence. Prespecified subgroup analyses were used to identify the potential effect modifiers.
After an average follow-up of 8.86 years (900,871.67 person-years), a total of 402 pancreatic cancer cases were observed. In the fully adjusted model, participants in the highest quartile of dietary diabetes risk reduction score were found to have a reduced risk of pancreatic cancer compared with those in the lowest quartile [HR: 0.62; 95% confidence interval (CI): 0.44, 0.86; P = 0.004], which remained in a series of sensitivity analyses. Subgroup analyses further found that this favorable association was more pronounced in current or former smokers (HR: 0.48; 95% CI: 0.30, 0.77) than in never smokers (HR: 0.71; 95% CI: 0.44, 1.15), although the interaction test did not reach statistical significance (P = 0.095).
Greater adherence to type 2 diabetes prevention diet is associated with a lower risk of pancreatic cancer in this US population. More studies are needed to confirm our findings.
2型糖尿病预防饮食可降低2型糖尿病风险，其机制与胰腺癌存在重叠。我们进行了一项前瞻性研究，以检验坚持这种饮食模式是否与降低胰腺癌风险相关。
确定了一个基于人群的队列，包括101,729名美国成年人。计算饮食糖尿病风险降低评分以反映对这种饮食模式的坚持程度，分数越高表示坚持程度越高。使用Cox回归计算胰腺癌发病率的风险比（HRs）。预先设定的亚组分析用于确定潜在的效应修饰因素。
平均随访8.86年（900,871.67人年）后，共观察到402例胰腺癌病例。在完全调整模型中，发现饮食糖尿病风险降低评分最高四分位数的参与者与最低四分位数的参与者相比，胰腺癌风险降低[HR：0.62；95%置信区间（CI）：0.44, 0.86；P = 0.004]，这在一系列敏感性分析中保持不变。亚组分析进一步发现，这种有利关联在当前或既往吸烟者中（HR：0.48；95% CI：0.30, 0.77）比从不吸烟者中（HR：0.71；95% CI：0.44, 1.15）更明显，尽管交互检验未达到统计学显著性（P = 0.095）。
在美国人群中，更高程度地坚持2型糖尿病预防饮食与较低的胰腺癌风险相关。需要更多研究来证实我们的发现。
