Department of Clinical Nutrition, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Avenue, Nan'an District, Chongqing, 400010, China.
J Transl Med. 2023 Oct 2;21(1):684. doi: 10.1186/s12967-023-04555-z.
There is little prospective evidence exists about whether adherence to a diabetes risk reduction diet (DRRD) is related to a significant reduction in renal cancer risk. We sought to clarify whether adherence to DRRD was associated with a reduced risk of renal cancer in a US population.
A population-based cohort of 101,755 American adults was identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. A DRRD score was calculated to assess adherence to this dietary pattern, where increased scores indicated greater adherence. The relationship between DRRD score and risk of renal cancer was assessed based on the hazard ratios (HRs) and 95% confidence intervals (CIs), which were both calculated using Cox regression. Non-linear association was determined through restricted cubic spline regression. Potential effect modifiers were identified through subgroup analyses.
Over a mean follow-up of 8.8 years, 446 renal cancers were detected. In this analysis, the fully adjusted model depicted a notable 29% reduction in the risk of renal cancer among individuals in the highest quartile of DRRD score in comparison with the lowest quartile individuals (HR: 0.71; 95% CI = 0.54, 0.94; P = 0.008). This association remained consistent across a series of sensitivity analyses. A non-linear inverse dose-response association between renal cancer risk with DRRD score was observed (P = 0.026). Subgroup analyses showed that this favorable link was more prominent in participants with low Healthy Eating Index-2015 (P = 0.015). Regarding the individual components of DRRD, a decrease in the risk of renal cancer was linked to increased intake of cereal fiber and whole fruit, and lower sugar-sweetened beverage consumption (all P < 0.05).
Our findings indicate that individuals adhering to DRRD are associated with a reduction in the risk of renal cancer.
目前很少有前瞻性证据表明，减少糖尿病风险的饮食（DRRD）是否与降低肾癌风险有关。我们试图在美国人群中阐明遵循 DRRD 是否与降低肾癌风险相关。
从前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中确定了 101755 名美国成年人的基于人群的队列。计算了 DRRD 评分以评估对这种饮食模式的依从性，其中得分增加表示依从性更高。使用 Cox 回归评估了 DRRD 评分与肾癌风险之间的关系，计算了风险比（HR）和 95%置信区间（CI）。通过限制性三次样条回归确定非线性关联。通过亚组分析确定潜在的效应修饰剂。
在平均 8.8 年的随访中，发现了 446 例肾癌。在这项分析中，与最低四分位的个体相比，DRRD 评分最高四分位的个体的肾癌风险降低了 29%（HR：0.71；95%CI=0.54，0.94；P=0.008）。这种关联在一系列敏感性分析中保持一致。DRRD 评分与肾癌风险之间存在非线性反比剂量反应关联（P=0.026）。亚组分析表明，这种有利联系在健康饮食指数-2015 评分低的参与者中更为明显（P=0.015）。关于 DRRD 的各个组成部分，降低肾癌风险与增加谷物纤维和全水果的摄入量以及减少含糖饮料的摄入量有关（均 P<0.05）。
我们的研究结果表明，遵循 DRRD 的个体与降低肾癌风险相关。
