Tecalco-Cruz Angeles C, Zepeda-Cervantes Jesús, Ortega-Domínguez Bibiana
Programa en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), Apdo. Postal 03100, Ciudad de México, México.
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Apdo. Postal 04510, Ciudad de México, México.
Mol Biol Rep. 2021 Nov;48(11):7517-7526. doi: 10.1007/s11033-021-06792-1. Epub 2021 Oct 16.
Estrogens are hormones that play a critical role during development and growth for the adequate functioning of the reproductive system of women, as well as for maintaining bones, metabolism, and cognition. During menopause, the levels of estrogens are decreased, altering their signaling mediated by their intracellular receptors such as estrogen receptor alpha and beta (ERα and ERβ), and G protein-coupled estrogen receptor (GPER). In the brain, the reduction of molecular pathways mediated by estrogenic receptors seems to favor the progression of Alzheimer's disease (AD) in postmenopausal women. In this review, we investigate the participation of estrogen receptors in AD in women during aging.
雌激素是一类激素，在女性生殖系统的发育和生长过程中发挥着关键作用，对于维持骨骼、新陈代谢和认知功能也至关重要。在更年期，雌激素水平下降，改变了其通过细胞内受体如雌激素受体α和β（ERα和ERβ）以及G蛋白偶联雌激素受体（GPER）介导的信号传导。在大脑中，由雌激素受体介导的分子通路的减少似乎有利于绝经后女性阿尔茨海默病（AD）的进展。在这篇综述中，我们研究了衰老过程中雌激素受体在女性AD中的作用。
