Tecalco-Cruz Angeles C, López-Canovas Lilia, Azuara-Liceaga Elisa
Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), Apdo, Postal 03100, Ciudad de México, Mexico.
Metab Brain Dis. 2023 Mar;38(3):783-793. doi: 10.1007/s11011-023-01161-2. Epub 2023 Jan 14.
Estrogen receptor alpha (ERα) is a transcription factor activated by estrogenic hormones to regulate gene expression in certain organs, including the brain. In the brain, estrogen signaling pathways are central for maintaining cognitive functions. Herein, we review the neuroprotective effects of estrogens mediated by ERα. The estrogen/ERα pathways are affected by the reduction of estrogens in menopause, and this event may be a risk factor for neurodegeneration associated with Alzheimer's disease in women. Thus, developing a better understanding of estrogen/ERα signaling may be critical for defining new biomarkers and potential therapeutic targets for Alzheimer's disease in women.
雌激素受体α（ERα）是一种转录因子，可被雌激素激活以调节某些器官（包括大脑）中的基因表达。在大脑中，雌激素信号通路是维持认知功能的核心。在此，我们综述了由ERα介导的雌激素的神经保护作用。雌激素/ERα通路会受到绝经后雌激素减少的影响，这一情况可能是女性与阿尔茨海默病相关的神经退行性变的一个危险因素。因此，更好地理解雌激素/ERα信号传导对于确定女性阿尔茨海默病的新生物标志物和潜在治疗靶点可能至关重要。
