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增强的 Sp1/YY1 表达指导转录,介导 VEGF 刺激的妊娠相关人子宫动脉内皮细胞 HS 产生。

Enhanced Sp1/YY1 Expression Directs Transcription to Mediate VEGF-Stimulated Pregnancy-Dependent HS Production in Human Uterine Artery Endothelial Cells.

机构信息

Department of Obstetrics and Gynecology, University of California, Irvine.

出版信息

Hypertension. 2021 Dec;78(6):1902-1913. doi: 10.1161/HYPERTENSIONAHA.121.18190. Epub 2021 Oct 18.

Abstract

[Figure: see text].

摘要

[图:见正文]。

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Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ.
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17β-Estradiol nongenomically induces vascular endothelial HS release by promoting phosphorylation of cystathionine γ-lyase.
J Biol Chem. 2019 Oct 25;294(43):15577-15592. doi: 10.1074/jbc.RA119.008597. Epub 2019 Aug 22.
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Chemical Biology of HS Signaling through Persulfidation.
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