塑造生命早期的长寿：发育中的 ROS 和 H3K4me3 设定生物钟。
Shaping longevity early in life: developmental ROS and H3K4me3 set the clock.
机构信息
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, USA.
出版信息
Cell Cycle. 2021 Nov;20(22):2337-2347. doi: 10.1080/15384101.2021.1986317. Epub 2021 Oct 17.
Abstract
Studies in have revealed that even a genetically identical population of animals exposed to the same environment displays a remarkable level of variability in individual lifespan. Stochasticity factors, occurring seemingly by chance or at random, are thought to account for a large part of this variability. Recent studies in our lab using now revealed that naturally occurring variations in the levels of reactive oxygen species experienced early in life contribute to the observed lifespan variability, and likely serve as stochasticity factors in aging. Here, we will highlight how developmental events can positively shape lifespan and stress responses via a redox-sensitive epigenetic regulator, and discuss the outstanding questions and future directions on the complex relationship between reactive oxygen species and aging.
摘要
研究表明，即使是暴露在相同环境中的遗传上完全相同的动物群体，其个体寿命也表现出显著的变异性。随机因素，似乎是偶然或随机发生的，被认为是这种变异性的很大一部分原因。我们实验室最近的研究使用 现在表明，生命早期经历的活性氧水平的自然变化导致了观察到的寿命变异性，并可能作为衰老过程中的随机性因素。在这里，我们将重点介绍发育事件如何通过一种氧化还原敏感的表观遗传调节剂积极塑造寿命和应激反应，并讨论活性氧与衰老之间复杂关系的悬而未决的问题和未来方向。
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