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儿童跟骨尤文肉瘤切除后诱导膜重建:3 例报告

Induced-Membrane Reconstruction After Calcaneum's Ewing Sarcoma in Children: A Report of 3 Cases.

机构信息

Department of Pediatric Orthopedics, Armand-Trousseau Hospital, Sorbonne University, Paris, France.

Department of Pediatric Orthopedics, Armand-Trousseau Hospital, Sorbonne University, Paris, France.

出版信息

J Foot Ankle Surg. 2022 Jul-Aug;61(4):e5-e8. doi: 10.1053/j.jfas.2021.09.020. Epub 2021 Sep 22.

Abstract

Calcaneus's Ewing sarcoma is a rare location with a poor prognosis and remains challenging for tumor surgery. We present 3 cases of calcaneus resection for Ewing sarcoma in children and its reconstruction managed by induced-membrane technique. To our knowledge, this technique has never been published for hindfoot's tumor management. Three children (aged from 9 to 14 years) had partial or total resection of calcaneus initially replaced by a cement spacer. The second step consisted of removing the cement and filling the membrane cavity with autograft taken from the ipsilateral iliac crest, potentially combined with bone substitute. In the meantime, children received chemotherapy and possibly radiotherapy according to the Euro E.W.I.N.G. 99 protocol. It was possible to optimize bone formation as we carried out the bone grafting procedure sometime after the treatments. In one case, the evolution was marked by local septic complication, 9 months after resection, and by tumor recurrence in presacral soft tissues treated with radiotherapy and chemotherapy. Partial weightbearing was allowed after 6 weeks of cast, under the protection of a splint. Graft consolidation was achieved at a median of 3.2 months (3-3.5) for all. After a median follow-up of 9 years (5-13), all preserved their limb and were considered in remission. The 3 children reached adulthood, with a median age of 21 years (19-24.8). At last follow-up, median Musculoskeletal Tumor Score was 73% (63-87), and median American Orthopaedic Foot and Ankle Society hind foot score was 78 (72-87).

摘要

跟骨尤文肉瘤是一种罕见的部位,预后较差,肿瘤手术仍然具有挑战性。我们报告了 3 例儿童跟骨尤文肉瘤切除及其重建采用诱导膜技术。据我们所知,该技术从未用于后足肿瘤的治疗。3 例儿童(年龄 9 至 14 岁)最初接受部分或全部跟骨切除,并用水泥 spacer 替代。第二步是去除水泥,并将取自同侧髂嵴的自体移植物填充到膜腔中,可能与骨替代物结合。同时,根据 Euro E.W.I.N.G. 99 方案,儿童接受化疗和可能的放疗。在治疗后进行骨移植手术,可以优化骨形成。在 1 例病例中,在切除后 9 个月,出现局部感染并发症,以及骶前软组织肿瘤复发,经放疗和化疗治疗。在石膏固定 6 周后,可以部分负重,在夹板的保护下。所有患者的移植物均在 3.2 个月(3-3.5)的中位数时间内达到骨整合。中位随访 9 年(5-13 年)后,所有患者均保留肢体,且处于缓解状态。3 名儿童均已成年,中位年龄为 21 岁(19-24.8 岁)。末次随访时,中位肌肉骨骼肿瘤评分 73%(63-87),美国矫形足踝协会后足评分 78 分(72-87 分)。

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