Cascade Eye & Skin Centers, University Place, WA, USA.
J Cosmet Dermatol. 2022 Jun;21(6):2497-2507. doi: 10.1111/jocd.14447. Epub 2021 Oct 18.
Hyperpigmentation is a common cosmetic concern that significantly impacts self-esteem. A skincare regimen has been developed to improve the appearance, tone, texture, and luminosity of subjects with facial hyperpigmentation (Even Up Hyperpigmentation Regimen; Colorescience, Inc., Carlsbad, CA).
The objective of this open-label trial was to assess the efficacy and tolerability of this regimen for treating facial hyperpigmentation.
PATIENTS/METHODS: Subjects with moderate-to-severe facial hyperpigmentation (N = 33) were randomized to those not using prescription, advanced or physician-dispensed skin care products (Group A, n = 23) and those currently using prescription, advanced or physician-dispensed skincare products for facial hyperpigmentation (Group B, n = 10). Both groups were provided three skincare products comprising the hyperpigmentation regimen and instructions for use. Subjects were evaluated at baseline and Weeks 2, 4, 8 and 12.
The overall median (range) baseline MASI score at baseline was 9.0 (2, 31), decreasing by 0.0 (-7, 0) points at Week 2 (p = 0.002), 0.6 (-8, 0) points at Week 4 (p < 0.0001), 1.5 (-16, 0) points by Week 8 (p < 0.0001) and 2.4 (-20, 0) points at Week 12 (p < 0.0001). At Week 12, the overall median improvement in MASI score was 26% and higher for Group B (32% vs. 22%). By Week 2, subjects reported lighter, less noticeable brown spots (76%), brighter, more luminous skin (88%), more even skin tone (67%), and healthier look and feel (85%). Improvements continued throughout the study. No adverse events were observed or reported.
This regimen addresses facial hyperpigmentation and protects skin against the damaging effects of ultraviolet and high energy visible light (HEV). It is safe to use on all skin types and tones.
色素沉着是一种常见的美容问题，严重影响自尊心。已经开发出一种护肤方案来改善面部色素沉着患者的外观、肤色、质地和光泽度（Even Up 色素沉着方案；Colorescience，Inc.，加利福尼亚州卡尔斯巴德）。
本开放性试验的目的是评估该方案治疗面部色素沉着的疗效和耐受性。
患者/方法：中度至重度面部色素沉着患者（N=33）随机分为未使用处方、高级或医生处方护肤品的患者（A 组，n=23）和当前使用处方、高级或医生处方护肤品治疗面部色素沉着的患者（B 组，n=10）。两组均提供三种护肤产品，包括色素沉着方案和使用说明。患者在基线和第 2、4、8 和 12 周进行评估。
总体中位数（范围）基线 MASI 评分基线为 9.0（2，31），第 2 周下降 0.0（-7，0）点（p=0.002），第 4 周下降 0.6（-8，0）点（p<0.0001），第 8 周下降 1.5（-16，0）点（p<0.0001），第 12 周下降 2.4（-20，0）点（p<0.0001）。第 12 周，MASI 评分的总体中位数改善为 26%，B 组更高（32%比 22%）。第 2 周，患者报告说棕色斑点更浅、更不明显（76%），皮肤更亮、更有光泽（88%），肤色更均匀（67%），外观和感觉更健康（85%）。改善持续整个研究。未观察到或报告不良事件。
该方案可治疗面部色素沉着，并保护皮肤免受紫外线和高能可见光（HEV）的损害。它可以安全用于所有皮肤类型和肤色。
