Karcı Bi Lge, Oncu Elif
Bi̇lge Karcı, Alanya Alaaddin Keykubat University, Faculty of Dentistry, Department of Periodontology, Alanya, Antalya, Turkey.
Elif Oncu, Necmettin Erbakan University, Faculty of Dentistry, Department of Periodontology, Konya, Turkey.
Acta Stomatol Croat. 2021 Sep;55(3):238-247. doi: 10.15644/asc55/3/1.
This study aimed to evaluate the levels of TNF-α, PGE, RANKL, RANK, OPG, the markers of periimplant bone loss in peri-implant crevicular fluid obtained around standard and extra short implants. Moreover, the levels of putative oral pathogens were investigated in the submucosal biofilm samples.
The implants were divided into two groups according to their lengths: standard (≥8 mm) and extra short (4 mm). A total of 60 implants were researched in 30 patients. The probing depth (PD), clinical attachment level (CAL), presence of bleeding on probing (BOP), 3-year survival rate (CSR), and bone loss (BL) were measured.
No statistically significant difference was found in the values of PD, CAL, BOP, CSR, and BL between the groups (P> 0.05). Total amounts of PGE, TNF-α, RANKL, RANK, OPG, and RANKL/OPG were not statistically significantly different between the groups (P> 0.05). The abundance , , , , and was compared between the groups and the results were not statistically significant (P> 0.05).
The results of this study suggested that PGE, TNF-α, RANKL, RANK, OPG, and RANKL/OPG in PICF, as well as microbiological parameters in submucosal biofilms, were similar between standard (≥8 mm) and extra short (4 mm) implants. Therefore, the implant length does not seem to influence the bone loss, levels of osteoimmunological and microbiological markers in the peri-implant tissues and survival rates.
本研究旨在评估标准种植体和超短种植体周围龈沟液中肿瘤坏死因子-α（TNF-α）、前列腺素E（PGE）、核因子κB受体活化因子配体（RANKL）、核因子κB受体活化因子（RANK）、骨保护素（OPG）的水平，这些是种植体周围骨吸收的标志物。此外，还研究了黏膜下生物膜样本中假定的口腔病原体水平。
根据种植体长度将其分为两组：标准种植体（≥8mm）和超短种植体（4mm）。对30例患者的60枚种植体进行研究。测量探诊深度（PD）、临床附着水平（CAL）、探诊出血（BOP）情况、3年存留率（CSR）和骨吸收（BL）。
两组间PD、CAL、BOP、CSR和BL值无统计学显著差异（P>0.05）。两组间PGE、TNF-α、RANKL、RANK、OPG总量以及RANKL/OPG无统计学显著差异（P>0.05）。比较两组间[此处原文缺失具体比较指标]的丰度，结果无统计学显著差异（P>0.05）。
本研究结果表明，标准种植体（≥8mm）和超短种植体（4mm）周围龈沟液中的PGE、TNF-α、RANKL、RANK、OPG以及RANKL/OPG，与黏膜下生物膜中的微生物学参数相似。因此，种植体长度似乎不影响种植体周围组织的骨吸收、骨免疫和微生物学标志物水平以及存留率。
