Hussein Rudha Naser, Al Hamdi Khalil Ismail, Mansour Abbas Ali
Najaf Health directorate, Najaf, Iraq.
Department of Medicine, College of Medicine, University of Basrah, Basrah, Iraq.
Postepy Dermatol Alergol. 2021 Aug;38(4):603-607. doi: 10.5114/ada.2021.108907. Epub 2021 Jan 17.
Hyperandrogenemia is the most frequent endocrine disorder in women causing a variety of adverse metabolic disturbances. Establishing the diagnosis of androgen overproduction has significant implications for the follow-up and treatment of patients.
To investigate the severity of hirsutism and its correlation with serum androgen in women with hirsutism from Basrah (Southern Iraq).
This was a cross-sectional study of 300 hirsute women, mean age: 26.6 ±7.1 years with a modified Ferriman and Gallwey (mFG) score of 8 or higher. Assessment of hirsutism severity was performed and hormonal markers including total testosterone (TT), calculated free testosterone (FT) and dehydroepiandrosterone sulfate (DHEA-S), were measured.
There was a significant correlation between the severity of hirsutism using mFG score and FT, TT levels ( < 0.001 and < 0.047, respectively), while no association was seen between mFG score and DHEA-S.
Our data suggest that FT and, to a less extent, TT were important biochemical hyperandrogenism markers that correlate with severity of hirsutism. DHEA-S was not found to be beneficial.
高雄激素血症是女性中最常见的内分泌紊乱疾病，会引发多种不良代谢紊乱。确立雄激素过量产生的诊断对患者的随访和治疗具有重要意义。
调查伊拉克南部巴士拉多毛症女性的多毛严重程度及其与血清雄激素的相关性。
这是一项对300名多毛女性的横断面研究，平均年龄为26.6±7.1岁，改良的费里曼和盖尔韦（mFG）评分在8分及以上。对多毛严重程度进行评估，并测量包括总睾酮（TT）、计算得出的游离睾酮（FT）和硫酸脱氢表雄酮（DHEA-S）在内的激素指标。
使用mFG评分得出的多毛严重程度与FT、TT水平之间存在显著相关性（分别为<0.001和<0.047），而mFG评分与DHEA-S之间未发现关联。
我们的数据表明，FT以及在较小程度上的TT是与多毛严重程度相关的重要生化高雄激素血症标志物。未发现DHEA-S有相关性。
