Medical Faculty, Department of Obstetrics and Gynecology, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2011 Feb;154(2):167-71. doi: 10.1016/j.ejogrb.2010.10.001. Epub 2010 Nov 1.
OBJECTIVE(S): To evaluate a modified Ferriman-Gallwey (mFG) scoring system and serum total testosterone (tT) and dehydroepiandrosterone sulfate (DHEAS) levels, in women with polycystic ovary syndrome (PCOS) and in control subjects.
Women with any gynecological problem who presented to the Kahramanmaras Sutcuimam University Medical Faculty Gynecology and Obstetric Outpatient Clinic in the Mediterranean region of Turkey were assessed prospectively. Oligo-anovulation, clinical and biochemical hyperandrogenism, and PCO appearance on ultrasound that met the 2003 Rotterdam Consensus Criteria were used for PCOS diagnosis. Group 1 consisted of 43 cases with a diagnosis of PCOS and group 2 (control group) consisted of 75 age and BMI matched control subjects without PCOS.
In groups 1 and 2, clinical hyperandrogenism (hirsutism) appearance ratio was 86.0% (37/43) and 18.0% (15/75) (p < 0.001); while biochemical hyperandrogenism (high serum tT or DHEAS level) was 65.1% (28/43) and 36% (27/75) (p < 0.05), respectively. In groups 1 and 2, mean serum tT levels were 115.2 and 73.4 ng/dL (p < 0.001), mean serum DHEAS levels were 256.1 and 177.7 ng/dL (p < 0.001), and mean hirsutism scores were 11.2 and 5.5 (p < 0.001), respectively. Serum mean tT, DHEAS and hirsutism scores for group 1 were significantly higher than those of group 2 (<0.001). No correlation was observed between BMI and the hirsutism scores or the biochemical hyperandrogenism in both groups.
CONCLUSION(S): In our study, mean serum androgen levels and hirsutism ratio in the PCOS group were higher than the control group. These values were also substantially higher than those previously published in the literature.
评估改良的 Ferriman-Gallwey（mFG）评分系统以及血清总睾酮（tT）和硫酸脱氢表雄酮（DHEAS）水平，在多囊卵巢综合征（PCOS）患者和对照组中的应用。
前瞻性评估土耳其地中海地区 Kahramanmaras Sutcuimam 大学医学系妇科和产科门诊的任何妇科问题的女性。稀发排卵、临床和生化高雄激素血症、以及符合 2003 年鹿特丹共识标准的超声多囊卵巢表现用于 PCOS 诊断。第 1 组由 43 例 PCOS 患者组成，第 2 组（对照组）由 75 例年龄和 BMI 匹配的无 PCOS 对照组组成。
在第 1 组和第 2 组中，临床高雄激素血症（多毛症）表现比例分别为 86.0%（37/43）和 18.0%（15/75）（p<0.001）；而生化高雄激素血症（血清 tT 或 DHEAS 水平升高）比例分别为 65.1%（28/43）和 36%（27/75）（p<0.05）。在第 1 组和第 2 组中，血清 tT 水平分别为 115.2 和 73.4ng/dL（p<0.001），血清 DHEAS 水平分别为 256.1 和 177.7ng/dL（p<0.001），多毛症评分分别为 11.2 和 5.5（p<0.001）。第 1 组的血清 tT、DHEAS 和多毛症评分明显高于第 2 组（p<0.001）。两组的 BMI 与多毛症评分或生化高雄激素血症均无相关性。
在本研究中，PCOS 组的血清雄激素水平和多毛症比例均高于对照组。这些值也明显高于文献中之前报道的值。
