Liu Linying, Huang Haijian, Li Yongbin, Zhang Ruochen, Wei Yongbao, Wu Weiwei
Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China.
Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Front Psychiatry. 2021 Oct 1;12:707326. doi: 10.3389/fpsyt.2021.707326. eCollection 2021.
Ketamine is a glutamate N-methyl D-aspartate receptor antagonist and an anaesthetic agent that has been effectively used to treat depression. However, ketamine has also been increasingly used for recreational purposes. The dissociative side-effects of ketamine use, such as hallucinations, are the reason for abuse. Additionally, long-term ketamine abuse has been highly associated with liver-gallbladder and urinary symptoms. The present study reports the case of a with an 8-year history of daily inhalation of ketamine. We investigated the association between ketamine abuse and the mechanism of its adverse effects, particularly encephalatrophy, and attempted to find a link between these disorders. These results would help us to better understand ketamine usage, ketamine abuse effects and the addictive mechanism. To the best of our knowledge, the present case is the first report of severe brain atrophy related to ketamine abuse. Details of the patient are presented and the mechanism of the encephalatropy-associated ketamine abuse is discussed. Furthermore, organ dysfunction following chronic ketamine abuse may indicate that the side effects are the result of comprehensive action on multiple regions in the brain.
氯胺酮是一种谷氨酸 N-甲基-D-天冬氨酸受体拮抗剂，也是一种已被有效用于治疗抑郁症的麻醉剂。然而，氯胺酮也越来越多地被用于娱乐目的。使用氯胺酮产生的分离性副作用，如幻觉，是其被滥用的原因。此外，长期滥用氯胺酮与肝胆和泌尿系统症状高度相关。本研究报告了一例有 8 年每日吸入氯胺酮病史的病例。我们调查了氯胺酮滥用与其不良反应机制之间的关联，特别是脑萎缩，并试图找出这些病症之间的联系。这些结果将有助于我们更好地了解氯胺酮的使用、氯胺酮滥用的影响及其成瘾机制。据我们所知，本病例是与氯胺酮滥用相关的严重脑萎缩的首例报告。文中呈现了患者的详细情况，并讨论了与氯胺酮滥用相关的脑萎缩机制。此外，慢性氯胺酮滥用后的器官功能障碍可能表明这些副作用是对大脑多个区域综合作用的结果。
