Digestive Diseases Centre, Derby Hospitals NHS Foundation Trust, Derby DE22 3NE, United Kingdom.
Singapore Med J. 2011 Mar;52(3):e52-5.
Ketamine is a dissociative anaesthetic agent that is still widely used in veterinary and human medicine. It is increasingly being used as a recreational hallucinogenic drug. Chronic ketamine abuse is known to account for lower urinary tract symptoms and urinary bladder dysfunction. There is now emerging evidence that ketamine misuse is also associated with abnormal liver function tests and biliary tract abnormality. We report three cases of chronic ketamine misuse in three young men who all presented with obstructive jaundice and biliary tract abnormality. We also describe the clinical features, radiological findings and potential underlying mechanisms for this new entity.
氯胺酮是一种分离麻醉剂，仍广泛应用于兽医和人类医学。它越来越多地被用作娱乐性致幻药物。已知慢性氯胺酮滥用会导致下尿路症状和膀胱功能障碍。现在有越来越多的证据表明，氯胺酮滥用也与肝功能检查异常和胆道异常有关。我们报告了三例年轻男性慢性氯胺酮滥用的病例，他们均表现为阻塞性黄疸和胆道异常。我们还描述了这种新实体的临床特征、影像学发现和潜在的潜在机制。
