自发性高血压大鼠和肾性高血压大鼠的脑血管神经支配改变

Altered cerebral vessel innervation in spontaneously hypertensive and renal hypertensive rats.

作者信息

Lee T J, Saito A

出版信息

J Hypertens Suppl. 1986 Oct;4(3):S201-3.

Abstract

The ultrastructural distributions of sympathetic and non-sympathetic nerve terminals in cerebral arteries of normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and one-kidney, one clip renal hypertensive rats (RHR) were examined. When compared with WKY, the SHR cerebral arteries receive denser sympathetic nerve terminals and fewer non-sympathetic nerve terminals. On the other hand, both sympathetic and non-sympathetic nerve terminals decrease in the cerebral arteries of RHR. These results suggest that the sympathetic vasoconstriction may surpass the non-sympathetic vasodilation in some brain regions of SHR, while the functional significance of cerebral sympathetic vasoconstrictor and non-sympathetic vasodilator nerves may decrease in RHR. The pattern of cerebral vessel innervation differs in different types of hypertension.

摘要

研究了正常血压的Wistar-Kyoto大鼠（WKY）、自发性高血压大鼠（SHR）和单肾单夹肾性高血压大鼠（RHR）脑动脉中交感和非交感神经末梢的超微结构分布。与WKY相比，SHR脑动脉接受的交感神经末梢更密集，而非交感神经末梢更少。另一方面，RHR脑动脉中的交感和非交感神经末梢均减少。这些结果表明，在SHR的某些脑区，交感神经血管收缩可能超过非交感神经血管舒张，而在RHR中，脑交感神经血管收缩和非交感神经血管舒张神经的功能意义可能降低。不同类型高血压的脑血管神经支配模式有所不同。