State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Front Immunol. 2021 Sep 29;12:730684. doi: 10.3389/fimmu.2021.730684. eCollection 2021.
The non-canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway is an important component of NF-κB transcription complex. Activation of this pathway mediates the development and function of host immune system involved in inflammation and viral infection. During hepatitis B virus (HBV) infection, there is a complex interaction between infected hepatocytes and the immune cells, which can hinder antiviral immune responses and is associated with pathological changes in liver tissue. Consistently, the host immune system is closely related to the severity of liver damage and the level of viral replication. Previous studies indicated that the non-canonical NF-κB signaling pathway was affected by HBV and might play an important regulatory role in the antiviral immunity. Therefore, systematically elucidating the interplay between HBV and non-canonical NF-κB signaling will contribute the discovery of more potential therapeutic targets and novel drugs to treat HBV infection.
非经典核因子 kappa-轻链增强子活化 B 细胞（NF-κB）信号通路是 NF-κB 转录复合物的重要组成部分。该通路的激活介导了宿主免疫系统的发育和功能，涉及炎症和病毒感染。在乙型肝炎病毒（HBV）感染期间，受感染的肝细胞与免疫细胞之间存在复杂的相互作用，这可能会阻碍抗病毒免疫反应，并与肝组织的病理变化有关。一致地，宿主免疫系统与肝损伤的严重程度和病毒复制水平密切相关。先前的研究表明，非经典 NF-κB 信号通路受 HBV 影响，可能在抗病毒免疫中发挥重要的调节作用。因此，系统阐明 HBV 与非经典 NF-κB 信号之间的相互作用将有助于发现更多治疗 HBV 感染的潜在治疗靶点和新型药物。
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