AlZeera Abdulla J, Alkhaja Aysha, Noor Dana H, Alsaffar Sayed Mohamed R
Internal Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain, Busaiteen, BHR.
Family Medicine, Dr. Jamal Al-Zeera Medical Center, Isa Town, BHR.
Cureus. 2021 Oct 11;13(10):e18669. doi: 10.7759/cureus.18669. eCollection 2021 Oct.
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated phenomenon characterized by demyelination of the central nervous system that displays numerous manifestations. It predominantly presents in children with a mean age range of five to eight years. ADEM remains a diagnosis of exclusion based on clinical and radiographic progression. Thus, it poses a diagnostic challenge. ADEM has been shown to be very responsive to steroids and exchange therapy. Here, we present an unusual case of ADEM in a 50-year-old female patient who, despite receiving an entire course of IV methylprednisolone and other conventional treatment methods, did not respond to the treatment.
急性播散性脑脊髓炎（ADEM）是一种免疫介导的现象，其特征为中枢神经系统脱髓鞘，有多种表现形式。它主要发生在平均年龄为5至8岁的儿童中。ADEM仍然是基于临床和影像学进展的排除性诊断。因此，它带来了诊断挑战。已证明ADEM对类固醇和置换疗法反应良好。在此，我们报告一例不寻常的ADEM病例，该病例为一名50岁女性患者，尽管接受了整个疗程的静脉注射甲基泼尼松龙及其他传统治疗方法，但对治疗无反应。
