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脑病的另一个病因:缬草根过量。

An Alternative Cause of Encephalopathy: Valerian Root Overdose.

作者信息

Freitas Corina, Khanal Subrat, Landsberg David, Kaul Viren

机构信息

Psychiatry, Crouse Health, Syracuse, USA.

Psychiatry and Behavioral Sciences, Upstate Medical University, Syracuse, USA.

出版信息

Cureus. 2021 Sep 6;13(9):e17759. doi: 10.7759/cureus.17759. eCollection 2021 Sep.

DOI:10.7759/cureus.17759
PMID:34659971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8493856/
Abstract

The interest in alternative therapeutics use has increased over the past few decades. Valerian, also known as "plant Valium," is a popular choice as a natural remedy for insomnia or anxiety. In order to ensure patient safety, clinicians need to be knowledgeable about commonly used alternative therapeutic products, their mechanisms of action, and potential pharmacological interactions. We present an unusual case of encephalopathy due to the combination of Valerian root, a plant with putative sedating properties, along with a natural "γ-aminobutyric acid (GABA) supplement." This case highlights the importance of thoroughly exploring alternative therapies when evaluating encephalopathy as well as the importance of being educated on the commonly used agents.

摘要

在过去几十年里,人们对替代疗法的使用兴趣有所增加。缬草,也被称为“植物安定”,是治疗失眠或焦虑的常用天然药物。为确保患者安全,临床医生需要了解常用的替代治疗产品、其作用机制以及潜在的药物相互作用。我们报告了一例因缬草根(一种具有假定镇静特性的植物)与天然“γ-氨基丁酸(GABA)补充剂”联合使用导致脑病的罕见病例。该病例强调了在评估脑病时全面探索替代疗法的重要性,以及了解常用药物的重要性。

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本文引用的文献

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A systematic review and quality assessment of complementary and alternative medicine recommendations in insomnia clinical practice guidelines.系统评价和质量评估在失眠临床实践指南中的补充和替代医学建议。
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US National Trends in Opioid-Related Hospitalizations Among Patients With Cancer.美国癌症患者阿片类药物相关住院治疗的国家趋势。
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Trends in the use of complementary health approaches among adults: United States, 2002-2012.2002 - 2012年美国成年人使用补充健康方法的趋势
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Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.缬草提取物和缬草烯酸在体外是5-HT5a受体的部分激动剂。
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Valerian.缬草
Am Fam Physician. 2003 Apr 15;67(8):1755-8.
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Bull World Health Organ. 2000;78(2):252-7.
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Effect of valerian on human sleep.缬草对人类睡眠的影响。
Psychopharmacology (Berl). 1985;87(4):406-9. doi: 10.1007/BF00432503.