Balderer G, Borbély A A
Psychopharmacology (Berl). 1985;87(4):406-9. doi: 10.1007/BF00432503.
The effect of an aqueous extract of valerian root on sleep was studied in two groups of healthy, young subjects. One group (N = 10) slept at home, the other (N = 8) in the sleep laboratory. Sleep was evaluated on the basis of questionnaires, self-rating scales and night-time motor activity. In addition, polygraphic sleep recordings and spectral analysis of the sleep EEG was performed in the laboratory group. Under home conditions, both doses of valerian extract (450 and 900 mg) reduced perceived sleep latency and wake time after sleep onset. Night-time motor activity was enhanced in the middle third of the night and reduced in the last third. The data suggest a dose-dependent effect. In the sleep laboratory, where only the higher dose of valerian was tested, no significant differences from placebo were obtained. However, the direction of the changes in the subjective and objective measures of sleep latency and wake time after sleep onset, as well as in night-time motor activity, corresponded to that observed under home conditions. There was no evidence for a change in sleep stages and EEG spectra. The results indicate that the aqueous valerian extract exerts a mild hypnotic action.
在两组健康的年轻受试者中研究了缬草根水提取物对睡眠的影响。一组（N = 10）在家中睡眠，另一组（N = 8）在睡眠实验室睡眠。根据问卷、自评量表和夜间运动活动对睡眠进行评估。此外，对实验室组进行了多导睡眠记录和睡眠脑电图的频谱分析。在家中条件下，两种剂量的缬草提取物（450毫克和900毫克）均缩短了感知到的入睡潜伏期和睡眠开始后的觉醒时间。夜间运动活动在午夜的中间三分之一时段增强，在最后三分之一时段减少。数据表明存在剂量依赖性效应。在睡眠实验室中，仅测试了较高剂量的缬草，与安慰剂相比未获得显著差异。然而，睡眠潜伏期和睡眠开始后的觉醒时间的主观和客观测量指标以及夜间运动活动的变化方向与在家中条件下观察到的一致。没有证据表明睡眠阶段和脑电图频谱发生了变化。结果表明缬草水提取物具有轻度催眠作用。
