Department of Neurology, Weihai Central Hospital Affiliated to Qingdao University and Weifang Medical College, Weihai, Shandong 264400, China.
Biomed Res Int. 2021 Oct 8;2021:3928060. doi: 10.1155/2021/3928060. eCollection 2021.
This study was performed to investigate the association between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) with cerebral microbleeds (CMBs) based on the apolipoprotein E () genotypes.
A total of 471 patients with acute cerebral infarction screened by magnetic sensitive imaging were enrolled in this study. Among them, twenty-seven cases of mixed CMBs were excluded. A total of 444 patients were divided into two groups according to the presence or absence of CMBs: CMBs group ( = 92) and noncerebral microbleeds group (nCMBs) ( = 352). Urine AD7c-NTP levels were measured using a human enzyme immunoassay kit.
In patients with lobar CMBs, there was an interaction between urine AD7c-NTP levels and genotypes ( = 0.01). In patients with allele, the odds ratio of lobar CMBs per standard deviation of urinary AD7c-NTP levels was 0.92 (95% CI: 0.70-1.19). In patients with or allele, the multivariate-corrected odds ratio of lobar CMBs per standard deviation of urinary AD7c-NTP levels was 2.95 (95% CI: 1.38-6.27).
A higher level of urinary AD7c-NTP is involved in lobar CMBs, not deep CMBs.
本研究旨在探讨载脂蛋白 E（）基因型与阿尔茨海默病相关神经元丝蛋白（AD7c-NTP）尿排泄量与脑微出血（CMBs）之间的关系。
本研究共纳入 471 例经磁敏感成像筛查的急性脑梗死患者，其中 27 例混合 CMBs 被排除。根据是否存在 CMBs，将 444 例患者分为 CMBs 组（=92）和非 CMBs 组（nCMBs）（=352）。采用人酶联免疫试剂盒检测尿 AD7c-NTP 水平。
在脑叶 CMBs 患者中，尿 AD7c-NTP 水平与基因型之间存在交互作用（=0.01）。在携带等位基因的患者中，尿 AD7c-NTP 水平每标准差的脑叶 CMBs 比值比为 0.92（95%CI：0.70-1.19）。在携带或等位基因的患者中，尿 AD7c-NTP 水平每标准差的脑叶 CMBs 比值比为 2.95（95%CI：1.38-6.27）。
较高水平的尿 AD7c-NTP 与脑叶 CMBs 有关，而与深部 CMBs 无关。
