Baumel Yuval, Yamin Hagar G, Cohen Dana
The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, 52900, Israel.
Heliyon. 2021 Oct 4;7(10):e08119. doi: 10.1016/j.heliyon.2021.e08119. eCollection 2021 Oct.
Essential tremor, a common, debilitating motor disorder, is thought to be caused by cerebellar malfunction. It has been shown that rhythmic Purkinje cell firing is both necessary and sufficient to induce body tremor. During tremor, cerebellar nuclei (CN) cells also display oscillatory activity. This study examined whether rhythmic activity in the CN characterizes the occurrence of body tremor, or alternatively, whether aberrant bursting activity underlies body tremor. Cerebellar nuclei activity was chronically recorded and analyzed in freely moving and in harmaline treated rats. CN neurons displayed rhythmic activity in both conditions, but the number of oscillatory neurons and the relative oscillation time were significantly higher under harmaline. The dominant frequencies of the oscillations were broadly distributed under harmaline and the likelihood that two simultaneously recorded neurons would co-oscillate and their oscillation coherence were significantly lower. It is argued that these alterations rather than neuronal rhythmicity per se underlie harmaline-induced body tremor.
特发性震颤是一种常见的、使人衰弱的运动障碍，被认为是由小脑功能障碍引起的。研究表明，浦肯野细胞的节律性放电对于诱发身体震颤既是必要的也是充分的。在震颤期间，小脑核（CN）细胞也表现出振荡活动。本研究考察了CN中的节律性活动是否表征了身体震颤的发生，或者相反，异常的爆发性活动是否是身体震颤的基础。在自由活动的大鼠和经 harmaline 处理的大鼠中，对小脑核活动进行了长期记录和分析。在两种情况下，CN 神经元均表现出节律性活动，但在 harmaline 处理下，振荡神经元的数量和相对振荡时间显著更高。在 harmaline 处理下，振荡的主导频率分布广泛，同时记录的两个神经元共同振荡的可能性及其振荡相干性显著更低。有人认为，这些改变而非神经元节律性本身是 harmaline 诱导的身体震颤的基础。
