嵌入查尔酮的聚氨酯作为生物材料：合成、表征及抗菌粘附
Chalcone embedded polyurethanes as a biomaterial: Synthesis, characterization and antibacterial adhesion.
作者信息
Sivakumar Ponnurengam Malliappan, Cometa Stefania, Alderighi Michele, Prabhawathi Veluchamy, Doble Mukesh, Chiellini Federica
机构信息
Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India; Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
出版信息
Carbohydr Polym. 2012 Jan 4;87(1):353-360. doi: 10.1016/j.carbpol.2011.07.061. Epub 2011 Aug 5.
An antibacterial dimethylamino-chalcone embedded multiblock copolymer (PCL-PEG) was synthesized and characterized using FT-IR, H NMR, SEM and SEC and the compound was characterized using FT-IR, H NMR, and C NMR. A 10% copolymer composite was prepared and casted as film to be used as a biomaterial and the copolymer films without the compound acted as control. TGA, DSC, AFM, SEM and EDAX analysis were performed for the above samples. Surface roughness (R) of the copolymer composite film was less when compared to the copolymer film which indicated the proper distribution of chalcone in the composite film. copolymer composite film was hydrophilic compared to copolymer film. Antibacterial adhesion studies were performed for copolymer composite polymer film and evaluated using CFU measurement and SEM analysis. Copolymer composite film shows promising antibacterial adhesion compared to the copolymer film. Hence the copolymer composite film can be used as a new biomaterial endowed with antibacterial properties.
合成了一种嵌入抗菌二甲基氨基查尔酮的多嵌段共聚物（PCL-PEG），并通过傅里叶变换红外光谱（FT-IR）、氢核磁共振（H NMR）、扫描电子显微镜（SEM）和尺寸排阻色谱（SEC）对其进行了表征，同时使用傅里叶变换红外光谱（FT-IR）、氢核磁共振（H NMR）和碳核磁共振（C NMR）对该化合物进行了表征。制备了10%的共聚物复合材料并浇铸成膜用作生物材料，不含该化合物的共聚物膜用作对照。对上述样品进行了热重分析（TGA）、差示扫描量热法（DSC）、原子力显微镜（AFM）、扫描电子显微镜（SEM）和能谱分析（EDAX）。与共聚物膜相比，共聚物复合膜的表面粗糙度（R）较小，这表明查尔酮在复合膜中分布均匀。与共聚物膜相比，共聚物复合膜具有亲水性。对共聚物复合聚合物膜进行了抗菌粘附研究，并通过菌落形成单位（CFU）测量和扫描电子显微镜（SEM）分析进行了评估。与共聚物膜相比，共聚物复合膜显示出良好的抗菌粘附性。因此，共聚物复合膜可作为一种具有抗菌性能的新型生物材料。
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