Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Science and Technology of Tangier (FSTT), 531748Abdelmalek Essaadi University (UAE), Tangier, Morocco.
Ahmed Ben Zayed Al Nahyan Center of Cancer Treatment, Tangier, Morocco.
Cancer Control. 2021 Jan-Dec;28:10732748211050587. doi: 10.1177/10732748211050587.
Nasopharyngeal carcinoma is a multifactorial disease mainly affecting the Asian and North African populations including Morocco. This study aimed to determine the epidemiological profile of nasopharyngeal carcinoma in Northern Morocco as well as its clinicopathological, therapeutic, and prognostic characteristics.
129 patients with nasopharyngeal carcinoma followed at the regional center of oncology of Tangier in the period between April 2017 and July 2019, and diagnosed elsewhere from March 2000 to February 2019, were included in this study. Statistical analysis of the data was realized using Statistical Package for the Social Sciences (SPSS) software.
Nasopharyngeal carcinoma (NPC) represented 5% of all cases with a median age of 50. The most affected age group was 40-54 years (41.1%). Of all patients, 65.9% were men and 34.1% were women with a sex ratio of 1.93 (Male/Female). Undifferentiated nasopharyngeal carcinomas were the most common histological type affecting 96.12% of patients. At diagnosis, the majority of patients (82.2%) had an advanced stage of NPC (III, VIa, b, c) including 5.4% of metastatic cases (IVc). Most cases (86%) had lymph node involvement with cervical mass being the most common clinical presentation. 81.4% of patients received radiotherapy combined with chemotherapy. Among these patients, 54.3% had concurrent radiochemotherapy preceded by induction chemotherapy. The 5-year overall survival (OS) was 86.8% for all patients. It represented 91.3% for early stages, 87.9% for locally advanced stages, and 57.1% for the metastatic stage significantly. The disease-free survival (DFS) at 5 years was 87.6% knowing that relapse occurred in 16 cases.
Nasopharyngeal carcinoma is a particular disease with a late declaration. It is common in Morocco as is the case in other endemic areas with a high prevalence. Patients' survival is significantly influenced by disease staging.
鼻咽癌是一种多因素疾病，主要影响包括摩洛哥在内的亚洲和北非人群。本研究旨在确定摩洛哥北部鼻咽癌的流行病学特征及其临床病理、治疗和预后特征。
本研究纳入了 2017 年 4 月至 2019 年 7 月在丹吉尔地区肿瘤中心就诊的 129 例鼻咽癌患者，以及 2000 年 3 月至 2019 年 2 月在其他地方诊断的患者。数据的统计分析使用了社会科学统计软件包（SPSS）。
鼻咽癌（NPC）占所有病例的 5%，中位年龄为 50 岁。受影响最严重的年龄组为 40-54 岁（41.1%）。所有患者中，65.9%为男性，34.1%为女性，性别比为 1.93（男性/女性）。未分化鼻咽癌是最常见的组织学类型，影响了 96.12%的患者。在诊断时，大多数患者（82.2%）处于 NPC 的晚期（III、VIa、b、c），包括 5.4%的转移性病例（IVc）。大多数病例（86%）有淋巴结受累，颈部肿块是最常见的临床表现。81.4%的患者接受了放化疗联合治疗。在这些患者中，54.3%的患者在接受诱导化疗后同时进行放化疗。所有患者的 5 年总生存率（OS）为 86.8%。早期阶段为 91.3%，局部晚期阶段为 87.9%，转移性阶段为 57.1%，差异有统计学意义。5 年无病生存率（DFS）为 87.6%，有 16 例患者复发。
鼻咽癌是一种特殊的疾病，表现为晚期发病。它在摩洛哥很常见，与其他流行地区一样，发病率很高。患者的生存与疾病分期显著相关。
