比较左心耳封堵术与口服抗凝药物预防非瓣膜性心房颤动患者卒中的效果：系统评价和荟萃分析方案。
Comparison of the effects of left atrial appendage closure and oral anticoagulants in preventing stroke in patients with non-valvular atrial fibrillation: A protocol for systematic review and meta-analysis.
机构信息
Department of Pharmacy, Chongming Branch of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 25 Nanmen Road, Chengqiao Town, Chongming District, Shanghai, China.
Department of Information, Chongming Branch of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 25 Nanmen Road, Chengqiao Town, Chongming District, Shanghai, China.
出版信息
Medicine (Baltimore). 2021 Sep 17;100(37):e27251. doi: 10.1097/MD.0000000000027251.
BACKGROUND
This study aims to analyze and evaluate the difference in efficacy between left atrial appendage closure (LAAC) and oral anticoagulants (OA) in preventing stroke in patients with non-valvular atrial fibrillation (NVAF) through the method of meta-analysis. The purpose is to provide for the prevention of stroke in patients with NVAF valuable treatment guidance.
METHODS
This study is a comprehensive collection of randomized controlled studies of LAAC and OA in the prevention of stroke in patients with NVAF, and searches PubMed, Embase, the Cochrane Library, Web of Science, CNKI, SinoMed, VIP Database, WANFANG Database, and other Chinese and English databases by combining subject words with free words, and the retrieval time is from the establishment of each database to June 1, 2021. At the same time, searching the included literature and literature of related reviews by manual. Two researchers independently conduct literature screening and quality evaluation. Statistical software RevMan 5.3 and Stata 12.0 were used for meta-analysis.
RESULTS
This study evaluating the difference in efficacy between LAAC and OA in preventing stroke in patients with NVAF will be published in high-quality medical academic journals.
CONCLUSION
This study will give the best treatment strategy to prevent stroke in patients with NVAF, and provide some reference for clinical medical staff.OSF registration number: DOI 10.17605/OSF.IO/2UXPA (https://osf.io/2uxpa).
背景
本研究旨在通过荟萃分析的方法分析和评价左心耳封堵术（LAAC）与口服抗凝剂（OA）在预防非瓣膜性心房颤动（NVAF）患者卒中方面的疗效差异，为 NVAF 患者的卒中预防提供有价值的治疗指导。
方法
本研究全面收集了 LAAC 和 OA 预防 NVAF 患者卒中的随机对照研究，通过主题词与自由词相结合的方式，检索 PubMed、Embase、Cochrane 图书馆、Web of Science、中国知网（CNKI）、中国生物医学文献数据库（SinoMed）、维普数据库（VIP）、万方数据库（WANFANG Database）等中英文数据库，检索时间为各数据库建库至 2021 年 6 月 1 日。同时，通过手工检索纳入文献及相关综述的参考文献。由 2 位研究者独立进行文献筛选和质量评价。采用统计软件 RevMan 5.3 和 Stata 12.0 进行荟萃分析。
结果
本研究将发表于高质量医学学术期刊，评价 LAAC 与 OA 在预防 NVAF 患者卒中方面的疗效差异。
结论
本研究将为 NVAF 患者的卒中预防给出最佳治疗策略，为临床医务人员提供一定参考。OSF 注册号：DOI 10.17605/OSF.IO/2UXPA（https://osf.io/2uxpa）。
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