伴有难治性溃疡性结肠炎的巨大肥厚性胃炎：临床挑战和文献复习。
Ménétrier's disease in a patient with refractory ulcerative colitis: a clinical challenge and review of the literature.
机构信息
IBD-unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Section of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Sicilia (omit), Italy.
出版信息
BMJ Case Rep. 2021 Oct 19;14(10):e246137. doi: 10.1136/bcr-2021-246137.
Ménétrier's disease (MD) is a rare disease of the stomach, characterised by hypertrophic gastric folds leading to protein loss. The association with ulcerative colitis (UC) is rare but has been reported in the literature. We report a case of a 29-year-old male affected by UC with an additional diagnosis of MD 3 years after UC diagnosis. UC was refractory to several treatment lines (thiopurines, infliximab, vedolizumab and ustekinumab), and the patient underwent colectomy. Octreotide was administered for MD normalising blood biochemistry, but it was not effective in inducing endoscopic remission of the stomach. Treatment options in patients with MD and UC are discussed.
梅内特里埃病（MD）是一种罕见的胃部疾病，其特征为胃皱襞肥厚导致蛋白质丢失。该病与溃疡性结肠炎（UC）相关联较为罕见，但已有文献报道。我们报告了一例 29 岁男性病例，该患者患有 UC，UC 诊断 3 年后又被诊断出患有 MD。UC 对多种治疗方案（硫唑嘌呤、英夫利昔单抗、vedolizumab 和 ustekinumab）均无反应，患者接受了结肠切除术。奥曲肽用于 MD 治疗，使血液生化指标恢复正常，但对诱导胃部内镜缓解无效。讨论了 MD 合并 UC 患者的治疗选择。
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