Sinha Aparna, Sharma Mukesh Kumar, Tripathi Komal, Duggal Nandini, Tiwari Vinay Kumar
Department of Plastic Surgery, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Department of Burns, Plastic and Reconstructive Surgery, PGIMER and Dr. R. M. L. Hospital, New Delhi, India.
Indian J Plast Surg. 2021 Sep 2;54(3):308-313. doi: 10.1055/s-0041-1734574. eCollection 2021 Sep.
Burn is a leading cause of fatality in a developing country. C-reactive protein levels (CRP) and procalcitonin (PCT) can be prognostic indicators for the burn patients' mortality. To assess serial levels of serum PCT and serum CRP as prognostic indicators in burns. In patients admitted with burns, alternate-day serum PCT and CRP were measured from the time of admission until the time of discharge or until survival. The change in trends of CRP and PCT serum levels were studied, and it was then correlated with mortality among these burn patients. The first-day value of serum PCT > 1772 pg/mL and serum CRP > 71 mg/mL or any value of serum PCT > 2163 pg/mL and of serum CRP > 90 mg/L indicate a poor prognosis in burns. The day-1 values of PCT and CRP were significantly higher in nonsurvivors than survivors in burns. The increasing trends of serum PCT and CRP levels are independent predictors of mortality in burns requiring prompt intervention. Rising PCT and CRP level denote poor prognosis in burns with an increased likelihood of death by 4.5 and 23.6 times, respectively.
烧伤是发展中国家的主要致死原因。C反应蛋白水平（CRP）和降钙素原（PCT）可作为烧伤患者死亡率的预后指标。为评估血清PCT和血清CRP的连续水平作为烧伤的预后指标。对于烧伤入院患者，从入院时起至出院时或直至存活期间，隔日测量血清PCT和CRP。研究了CRP和PCT血清水平的变化趋势，然后将其与这些烧伤患者的死亡率相关联。血清PCT首日值>1772 pg/mL且血清CRP>71 mg/mL，或血清PCT的任何值>2163 pg/mL且血清CRP>90 mg/L表明烧伤预后不良。烧伤非存活者的PCT和CRP首日值显著高于存活者。血清PCT和CRP水平的上升趋势是需要及时干预的烧伤死亡率的独立预测指标。PCT和CRP水平升高分别表明烧伤预后不良，死亡可能性增加4.5倍和23.6倍。
