Aberrant breakpoints in chronic myelogenous leukaemia; oncogenes and fragile sites.
作者信息
Huret J L, Tanzer J, Henry-Amar M
出版信息
Hum Genet. 1986 Dec;74(4):447-8. doi: 10.1007/BF00280504.
PMID:3466854
Abstract
Three hundred and twenty-five aberrant breakpoints in chronic myelogenous leukaemia (CML) with Philadelphia chromosome variant were reviewed. Eight chromosomal bands (3p21, 6p21, 7p22, 11q13, 12p13, 17p13, 17q21, and 17q25) were found to be highly involved. Apart from 17q25, all these bands correspond to oncogenes sites and/or sites involved as primary breakpoints in cancer.
摘要
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