School of Psychology, University of Wollongong, Wollongong 2522, Australia; Brain & Behaviour Research Institute, University of Wollongong, Wollongong 2522, Australia.
School of Psychology, University of Wollongong, Wollongong 2522, Australia; Brain & Behaviour Research Institute, University of Wollongong, Wollongong 2522, Australia.
Clin Neurophysiol. 2019 Aug;130(8):1256-1262. doi: 10.1016/j.clinph.2019.05.001. Epub 2019 May 9.
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders found in children. While an extensive literature has documented the EEG in this clinical population, few studies have investigated EEG throughout the lifespan in ADHD. This study aimed to investigate EEG maturational changes, in subjects with ADHD combined type, that spanned from childhood into adulthood.
Twenty five male adults with ADHD were assessed between the ages of 8-12 years and again as adults. At both ages, an EEG was recorded during an eyes-closed resting period, and power estimates were calculated for relative delta, theta, alpha and beta.
At the childhood assessment, the ADHD subjects had elevated posterior delta. Relative theta was elevated, with diminished alpha activity across all sites. Significant maturational changes were observed, with reductions in the delta and theta bands, and increases in the alpha and beta bands across all electrodes. In adulthood, relative to controls, diminished frontal delta and elevated global theta activity were apparent.
Substantial developmental changes occurred in the EEG of these subjects. These results identify important issues when using EEG as part of the diagnosis for ADHD.
This study is the first to explore EEG changes from childhood to adulthood over an 11 year period in the same subjects with ADHD.
注意力缺陷多动障碍（ADHD）是儿童中最常见的精神障碍之一。虽然大量文献记录了该临床人群的脑电图，但很少有研究调查 ADHD 患者整个生命周期的脑电图。本研究旨在调查 ADHD 混合型患者的脑电图成熟变化，这些患者的年龄从儿童期到成年期不等。
25 名男性 ADHD 成年患者在 8-12 岁和成年后接受评估。在这两个年龄阶段，在闭眼休息期间记录脑电图，并计算相对 delta、theta、alpha 和 beta 的功率估计值。
在儿童期评估时，ADHD 患者的后 delta 升高。相对 theta 升高，所有部位的 alpha 活动减少。观察到明显的成熟变化，所有电极的 delta 和 theta 带减少，alpha 和 beta 带增加。成年后，与对照组相比，额叶 delta 减少，全局 theta 活动升高。
这些患者的脑电图发生了重大的发育变化。这些结果在 ADHD 患者中首次确定了将 EEG 作为 ADHD 诊断的一部分时需要考虑的重要问题。
本研究是首次在同一批 ADHD 患者中探索从儿童期到成年期的脑电图变化，历时 11 年。
