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评估积极从事儿童和青少年精神病学实践的社区从业者诊断和治疗 DSM-5 轻度精神病综合征的倾向。

Evaluating the tendencies of community practitioners who actively practice in child and adolescent psychiatry to diagnose and treat DSM-5 attenuated psychotic syndrome.

机构信息

Department of Child and Adolescent Psychiatry, Ankara City Hospital, Üniversiteler, Bilkent Blv. No: 1, Çankaya, 06800, Ankara, Turkey.

Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

出版信息

Eur Child Adolesc Psychiatry. 2022 Oct;31(10):1635-1644. doi: 10.1007/s00787-021-01897-1. Epub 2021 Oct 20.

DOI:10.1007/s00787-021-01897-1
PMID:34669043
Abstract

The detection of individuals at clinical ultra-high risk for psychosis (CHR-P) may be a key limiting step for early interventions, and there is some uncertainty regarding the true clinical reliability of the CHR-P states. The aim of this study was to explore how practitioners who were in the direct treatment of children with psychiatric disorders [child psychiatry specialists/trainees (n = 227, n = 131), adult psychiatrists (n = 27), and child neurologists (n = 2)] perceive the DSM-5-Attenuated Psychosis Syndrome (DSM-5-APS), and their clinical routine practice in the treatment of it. Three vignettes describing fictional cases presented with symptoms of either DSM-5-Schizophrenia, DSM-5-APS, and no psychotic symptoms were created. We asked these practitioners to apply a DSM-5 diagnosis and to choose appropriate treatment(s) for these vignettes. Of the responders, 43% correctly diagnosed the APS vignette, whereas 37.4% mentioned that it had a full-blown psychotic episode. Regarding the therapeutic approach for the APS vignette, 72.1% of all practitioners chose a psychopharmacological intervention and 32% individual psychotherapy. This study showed that the diagnostic inter-rater reliability of the DSM-5-APS among child/adolescent mental health practitioners was consistent with the results from the DSM-5 field trials (Kappa = 0.46). Moreover, almost three in four practitioners endorsed psychopharmacological intervention as a treatment option for the DSM-5-APS case. The lack of evidence of psychopharmacological interventions in CHR-P situations emphasizes that the least harmful interventions should be recommended. Thus, our findings indicated a need for raising awareness regarding the CHR-P paradigm and its treatment as well as the development of solid guidelines that can be implemented in clinical practice.

摘要

个体处于精神病超高风险临床状态(CHR-P)的检测可能是早期干预的关键限制步骤,而 CHR-P 状态的真正临床可靠性存在一些不确定性。本研究旨在探讨直接治疗儿童精神障碍的从业者[儿童精神病学专家/受训者(n=227,n=131)、成人精神病学家(n=27)和儿童神经科医生(n=2)]如何看待 DSM-5-缓和性精神病综合征(DSM-5-APS),以及他们在治疗该病时的临床常规实践。我们创建了三个描述虚构病例的情景,这些病例表现出 DSM-5-精神分裂症、DSM-5-APS 和无精神病症状。我们要求这些从业者对这些病例进行 DSM-5 诊断,并为这些病例选择合适的治疗方法。在回答问题的从业者中,43%正确诊断了 APS 病例,而 37.4%则提到这是一个全面的精神病发作。关于 APS 病例的治疗方法,所有从业者中有 72.1%选择了精神药理学干预,32%选择了个体心理治疗。本研究表明,儿童/青少年心理健康从业者对 DSM-5-APS 的诊断组内可靠性与 DSM-5 现场试验的结果一致(Kappa=0.46)。此外,近四分之三的从业者将精神药理学干预作为 DSM-5-APS 病例的治疗选择之一。CHR-P 情况下缺乏精神药理学干预的证据强调,应该推荐危害最小的干预措施。因此,我们的研究结果表明,需要提高对 CHR-P 范式及其治疗的认识,并制定可在临床实践中实施的坚实指南。

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本文引用的文献

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Meta-analyzing the prevalence and prognostic effect of antipsychotic exposure in clinical high-risk (CHR): when things are not what they seem.对临床高风险(CHR)人群中抗精神病药物暴露的患病率和预后影响进行荟萃分析:当事情并非表面上看起来的那样。
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SHARP(上海精神病高危人群)研究中 517 名临床高风险个体的 3 年队列研究显示抗精神病药物治疗在精神分裂症预防中的真实世界效果。
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The "Reggio Emilia At-Risk Mental States" program: A diffused, "liquid" model of early intervention in psychosis implemented in an Italian Department of Mental Health.雷焦艾米利亚高危精神状态项目:一种精神分裂症早期干预的弥散性、“流动性”模式,在意大利一家心理健康部门实施。
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The use of video vignettes to measure health worker knowledge. Evidence from Burkina Faso.利用视频短片来衡量卫生工作者的知识。来自布基纳法索的证据。
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