Eggel-Hort Béatrice, Maisonneuve Emeline, Gonzalez Rodriguez Elena, Baud David
Service de gynécologie et obstétrique, Centre hospitalier du Valais Romand, 1951 Sion.
Université de Berne, Institute of Primary Health Care (BIHAM), 3012 Berne.
Rev Med Suisse. 2021 Oct 20;17(755):1774-1778.
Vitamin D deficiency affects more than half of the general population. During pregnancy vitamin D insufficiency is associated with a higher risk of complications such as an increased incidence of miscarriages. Preterm delivery, preeclampsia, gestational diabetes, growth retardation and low birth weight as well as postpartum hemorrhage are all pathologies whose incidence seems to be increased with hypovitaminosis D. This could be linked to the pregnancy changes of the immune system, on which vitamin D plays a well-known modulating role. Substitution, even if its benefit is not clearly established, should be considered as there are no side effects. Although lack of evidence regarding the timing of the introduction of treatment, substitution may be proposed before conception.
维生素D缺乏影响超过一半的普通人群。在孕期，维生素D不足与更高的并发症风险相关，如流产发生率增加。早产、先兆子痫、妊娠期糖尿病、生长发育迟缓、低出生体重以及产后出血等病症，其发生率似乎都因维生素D缺乏症而增加。这可能与孕期免疫系统的变化有关，而维生素D在其中发挥着众所周知的调节作用。即使替代疗法的益处尚未明确确立，但鉴于其没有副作用，仍应予以考虑。尽管缺乏关于开始治疗时机的证据，但可在受孕前建议进行替代治疗。
