Filippov V M, Petrachkov D V, Budzinskaya M V, Sidamonidze A L
Research Institute of Eye Diseases, Moscow, Russia.
Vestn Oftalmol. 2021;137(5. Vyp. 2):306-313. doi: 10.17116/oftalma2021137052306.
This literature review presents modern view on the pathogenesis of diabetic retinopathy (DR) paying particular attention to the molecular mechanisms leading to its development, as well as the manifestations of retinal neurodegeneration in such patients. Assessment of this condition and its clinical manifestations makes it possible to diagnose DR at the stage of absent initial vascular changes. Investigating the neurodegeneration mechanisms could supplement the existing understanding of the disease pathogenesis and could possibly help find new ways of treatment and prevention of DR.
本综述介绍了糖尿病视网膜病变（DR）发病机制的现代观点，特别关注导致其发展的分子机制，以及此类患者视网膜神经变性的表现。对这种情况及其临床表现进行评估，有助于在初始血管变化不明显的阶段诊断DR。研究神经变性机制可以补充对该疾病发病机制的现有认识，并可能有助于找到治疗和预防DR的新方法。
